A dynamic network perspective of chronic pain.

A dynamic network perspective of chronic pain.
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DOI:
10.1016/j.neulet.2012.05.001
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发表时间:
2012-06-29
影响因子:
2.5
通讯作者:
Apkarian AV
Apkarian AV
中科院分区:
医学4区
文献类型:
--
作者:
Farmer MA;Baliki MN;Apkarian AV

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我们简要总结了有关慢性疼痛的脑功能表征、静息状态脑活动的重组以及慢性疼痛的脑解剖学方面的最新进展。基于这些观察和关于网络结构特性的最新理论进展,我们提出了随着大脑发展成持续性疼痛,解剖和功能之间动态相互作用的一般概念,并概述了可能涉及慢性疼痛维持的中脑边缘学习机制的作用。
We briefly summarize recent advances regarding brain functional representation of chronic pain, reorganization of resting state brain activity, and of brain anatomy with chronic pain. Based on these observations and recent theoretical advances regarding network architecture properties, we develop a general concept of the dynamic interplay between anatomy and function as the brain progresses into persistent pain, and outline the role of mesolimbic learning mechanisms that are likely involved in maintenance of chronic pain.
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