Evaluating the validity of volume-based and surface-based brain image registration for developmental cognitive neuroscience studies in children 4 to 11 years of age.
Evaluating the validity of volume-based and surface-based brain image registration for developmental cognitive neuroscience studies in children 4 to 11 years of age.
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DOI：
10.1016/j.neuroimage.2010.05.075
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发表时间：
2010-10-15
期刊：
影响因子：
5.7
通讯作者：
Fischl, Bruce
中科院分区：
文献类型：
--
作者：
Ghosh, Satrajit S.;Kakunoori, Sita;Augustinack, Jean;Nieto-Castanon, Alfonso;Kovelman, Ioulia;Gaab, Nadine;Christodoulou, Joanna A.;Triantafyllou, Christina;Gabrieli, John D. E.;Fischl, Bruce
了解人类认知发展的神经生理学依赖于能够准确比较不同年龄人群大脑结构和功能神经成像数据的方法。一个基本的问题是，在儿童早期发生的大量大脑生长和相关的大脑形态变化是否允许对不同年龄的大脑结构和功能进行有效的比较。在这里，我们调查了是否可以在4-11岁的儿童中进行有效的比较，以及在使用基于体积与基于表面的配准方法来对齐这些年龄段的结构标志时是否存在差异。对应于距状沟，中央沟，和大脑外侧裂在两个半球的区域手动标记T1加权结构磁共振图像从31名儿童，年龄从4.2岁到11.2岁。当大脑使用12参数仿射变换、SPM的非线性归一化、仿射配准（ANTS）和FreeSurfer的基于表面的配准进行对齐时，计算这些手动标记区域的形状相似性和体积重叠的定量测量。在这个年龄范围内的参与者中，标准化到共同参考框架的配准误差低于常用的功能成像分辨率。基于表面的注册提供了显着更好的对齐皮质标志比基于体积的注册。此外，将儿童的大脑登记到一个共同的空间不会导致年龄较大和年龄较小的儿童之间的年龄相关的偏见，这使得准确比较4-11岁儿童的大脑激活的结构特性和模式成为可能。
Understanding the neurophysiology of human cognitive development relies on methods that enable accurate comparison of structural and functional neuroimaging data across brains from people of different ages. A fundamental question is whether the substantial brain growth and related changes in brain morphology that occur in early childhood permit valid comparisons of brain structure and function across ages. Here we investigated whether valid comparisons can be made in children from ages 4–11, and whether there are differences in the use of volume-based versus surface-based registration approaches for aligning structural landmarks across these ages. Regions corresponding to the calcarine sulcus, central sulcus, and Sylvian fissure in both the hemispheres were manually labeled on T1-weighted structural magnetic resonance images from 31 children ranging in age from 4.2 to 11.2 years old. Quantitative measures of shape similarity and volumetric-overlap of these manually labeled regions were calculated when brains were aligned using a 12-parameter affine transform, SPM's nonlinear normalization, a diffeomorphic registration (ANTS), and FreeSurfer's surface-based registration. Registration error for normalization into a common reference framework across participants in this age range was lower than commonly used functional imaging resolutions. Surface-based registration provided significantly better alignment of cortical landmarks than volume-based registration. In addition, registering children's brains to a common space does not result in an age-associated bias between older and younger children, making it feasible to accurately compare structural properties and patterns of brain activation in children from ages 4–11.
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影响因子：
5.7
作者：
Fischl, B;Sereno, MI;Dale, AM
通讯作者：
Dale, AM
影响因子：
5.7
作者：
Jenkinson, M;Bannister, P;Smith, S
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Smith, S
定位人类主要视觉皮层的功能和解剖边界。
影响因子：
5.7
作者：
Hinds O;Polimeni JR;Rajendran N;Balasubramanian M;Amunts K;Zilles K;Schwartz EL;Fischl B;Triantafyllou C
通讯作者：
Triantafyllou C
影响因子：
10.9
作者：
Avants, Brian B.;Schoenemann, P. Thomas;Gee, James C.
通讯作者：
Gee, James C.
影响因子：
5.7
作者：
Dale, AM;Fischl, B;Sereno, MI
通讯作者：
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