Moderate Champagne consumption promotes an acute improvement in acute endothelial-independent vascular function in healthy human volunteers
Moderate Champagne consumption promotes an acute improvement in acute endothelial-independent vascular function in healthy human volunteers
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适量饮用香槟可促进健康志愿者急性内皮依赖性血管功能的急剧改善
DOI：
10.1017/s0007114509992959
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发表时间：
2009
影响因子：
3.6
通讯作者：
J. Spencer
中科院分区：
文献类型：
--
作者：
Dr David Vauzour;Emily J Houseman;T. George;G. Corona;R. Garnotel;K. Jackson;Christelle Sellier;P. Gillery;O. Kennedy;J. Lovegrove;J. Spencer
流行病学研究表明，红酒消费量与心血管疾病的发病率呈负相关。然而，香槟酒的心脏保护潜力尚未得到充分研究。为了评估急性和中度饮用香槟酒是否能够调节血管功能，我们进行了一项随机、安慰剂对照、交叉干预试验。我们发现，饮用香槟酒（但不与酒精、碳水化合物和水果酸含量相匹配的对照）会在饮用后 4 小时和 8 小时内引起内皮依赖性血管舒张的急剧变化。尽管香槟酒和对照物在4小时时均诱导内皮依赖性血管反应性增加，但在任何时间点香槟酒或对照物诱导的血管效应之间没有显着差异。这些效应伴随着基质金属蛋白酶 (MMP-9) 浓度的急剧下降、氧化物质血浆水平的显着降低以及多种酚类代谢物的尿排泄增加。特别是，与对照干预相比，香槟酒干预后马尿酸、原儿茶酸和异阿魏酸的平均总排泄量均显着增加。我们的数据表明，每天适量饮用香槟酒可以通过提供能够提高一氧化氮生物利用度和降低基质金属蛋白酶活性的酚类成分来改善血管性能。
Epidemiological studies have suggested an inverse correlation between red wine consumption and the incidence of CVD. However, Champagne wine has not been fully investigated for its cardioprotective potential. In order to assess whether acute and moderate Champagne wine consumption is capable of modulating vascular function, we performed a randomised, placebo-controlled, cross-over intervention trial. We show that consumption of Champagne wine, but not a control matched for alcohol, carbohydrate and fruit-derived acid content, induced an acute change in endothelium-independent vasodilatation at 4 and 8 h post-consumption. Although both Champagne wine and the control also induced an increase in endothelium-dependent vascular reactivity at 4 h, there was no significant difference between the vascular effects induced by Champagne or the control at any time point. These effects were accompanied by an acute decrease in the concentration of matrix metalloproteinase (MMP-9), a significant decrease in plasma levels of oxidising species and an increase in urinary excretion of a number of phenolic metabolites. In particular, the mean total excretion of hippuric acid, protocatechuic acid and isoferulic acid were all significantly greater following the Champagne wine intervention compared with the control intervention. Our data suggest that a daily moderate consumption of Champagne wine may improve vascular performance via the delivery of phenolic constituents capable of improving NO bioavailability and reducing matrix metalloproteinase activity.
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影响因子：
15.9
作者：
GALIS, ZS;SUKHOVA, GK;LIBBY, P
通讯作者：
LIBBY, P
影响因子：
6.1
作者：
Dudley, Jocelyn I.;Lekli, Istvan;Das, Dipak K.
通讯作者：
Das, Dipak K.
检测心血管疾病和衰老中锰 SOD 和 SERCA 的序列特异性酪氨酸硝化。
DOI：
10.1152/ajpheart.01293.2005
发表时间：
2006
期刊：
American journal of physiology. Heart and circulatory physiology
影响因子：
--
作者：
Xu,Shanqin;Ying,Jia;Jiang,Bingbing;Guo,Wei;Adachi,Takeshi;Sharov,Viktor;Lazar,Harold;Menzoian,James;Knyushko,TatyanaV;Bigelow,Diana;Schöneich,Christian;Cohen,RichardA
通讯作者：
Cohen,RichardA
影响因子：
7.1
作者：
Lampe, JW
通讯作者：
Lampe, JW
乙醇对人体血管功能的直接影响。
DOI：
10.1152/ajpheart.01207.2003
发表时间：
2004
期刊：
American journal of physiology. Heart and circulatory physiology
影响因子：
--
作者：
Tawakol,Ahmed;Omland,Torbjørn;Creager,MarkA
通讯作者：
Creager,MarkA