Mechanical strengthening of fiberoptic microneedles using an elastomeric support.
Mechanical strengthening of fiberoptic microneedles using an elastomeric support.
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DOI：
10.1002/lsm.22026
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发表时间：
2012-07
影响因子：
2.4
通讯作者：
中科院分区：
文献类型：
--
作者：
由二氧化硅光纤制成的微针可以传输和收集光，这是相对于金属或硅微针的重要功能优势。这种增加的功能可以增强或甚至实现新的经皮基于光的临床诊断和治疗程序。由能够发光和检测的固体纤维制成的直径为100毫米的光纤微针被设计成穿透几毫米到组织中，同时最大限度地减少组织侵入和破坏。高纵横比（长度比直径）微针的机械强度（临界屈曲力）是一个潜在的问题，这促使我们发明了弹性体支撑装置。在这项研究中，我们已经测试了我们的假设，即将微针嵌入弹性体支撑介质中可能会增加微针临界屈曲力。测量了直径为55、70和110 μ m、长度为3 mm的二氧化硅微针在周围有和没有弹性体支撑物（PDMS，聚二甲基硅氧烷）的情况下的临界屈曲力。这些实验结果进行了比较产生的瑞利-里兹屈曲模型的理论计算。测量了直径为55和70 μ m的微针穿透离体猪皮肤所需的插入力。使用PDMS支撑件使直径为55、70和110 μ m的微针的临界屈曲力分别平均增加610%、290%和33%。瑞利-里兹模型的理论计算一致高估了实验确定的强化，但高度相关的更大的增强提供更薄的微针。在机械强化的辅助下，直径为55 μ m的微针能够重复穿刺。微针的临界屈曲力可以显著增加，以允许直径为55 - 110 μ m、长度为3 mm的极高纵横比微针穿透离体猪皮肤。通过这种强化方法，可以大大提高微针在潜在临床应用中的安全性和可靠性。
Microneedles made from silica fiberoptics permit transmission and collection of light, which is an important functional advantage over metal or silicon microneedles. This added functionality may enhance or even enable new percutaneous light-based clinical diagnostic and therapeutic procedures. Micron-diameter fiberoptic microneedles, created from solid fibers capable of light emission and detection, are designed to penetrate several millimeters into tissue while minimizing tissue invasion and disruption. The mechanical strength (critical buckling force) of high aspect ratio (length to diameter) microneedles is a potential problem, which has motivated our invention of an elastomeric support device. In this study, we have tested our hypothesis that embedding the microneedles in an elastomeric support medium may increase microneedle critical buckling force. The critical buckling force of silica microneedles with 55, 70, and 110 μm diameters and 3 mm lengths were measured with and without a surrounding elastomeric support (PDMS, polydimethylsiloxane). These experimental results were compared to theoretical calculations generated by the Rayleigh–Ritz buckling model. The insertion force required to penetrate ex vivo porcine skin was measured for microneedles with 55 and 70 μm diameters. Use of the PDMS support increased critical buckling force for microneedles of 55, 70, and 110 μm diameters by an average of 610%, 290%, and 33%, respectively. Theoretical calculations by the Rayleigh–Ritz model consistently overestimated the experimentally determined strengthening, but correlated highly with the greater enhancement offered to thinner microneedles. Aided by mechanical strengthening, microneedles 55 μm in diameter were able to repeatedly penetrate. The critical buckling force of microneedles can be increased substantially to allow extremely high-aspect ratio microneedles, 55–110 μm in diameter and 3 mm in length, to penetrate ex vivo porcine skin. By this strengthening method, the safety and reliability of microneedles in potential clinical applications can be considerably enhanced.
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影响因子：
10.8
作者：
Park, JH;Allen, MG;Prausnitz, MR
通讯作者：
Prausnitz, MR
DOI：
10.1115/1.4002192
发表时间：
2010-09-01
影响因子：
1.7
作者：
Kosoglu, Mehmet A.;Hood, Robert L.;Rylander, Christopher G.
通讯作者：
Rylander, Christopher G.
影响因子：
5.7
作者：
Kaushik, S;Hord, AH;Prausnitz, MR
通讯作者：
Prausnitz, MR
影响因子：
2.3
作者：
Byun, S;Lim, JM;Cho, D
通讯作者：
Cho, D
影响因子：
3.4
作者：
Ramasubramanian, M. K.;Barham, O. M.;Swaminathan, V.
通讯作者：
Swaminathan, V.