Multifractal analysis of nonlinear complexity of sacral skin blood flow oscillations in older adults.
Multifractal analysis of nonlinear complexity of sacral skin blood flow oscillations in older adults.
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DOI：
10.1007/s11517-011-0775-6
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发表时间：
2011-08
影响因子：
3.2
通讯作者：
Jan, Yih-Kuen
中科院分区：
文献类型：
--
作者：
Liao, Fuyuan;Struck, Bryan D.;MacRobert, Margo;Jan, Yih-Kuen
关键词：
本研究旨在探讨老年人皮肤血管扩张功能与血流振荡(BFO)非线性复杂性的关系。在20名具有不同血管扩张功能的老年受试者中，采用了一种无痛的快速局部加热方案。用激光多普勒血流仪测量皮肤血流波动。采用多重分形去趋势波动分析方法，量化了脑底血管闭锁的代谢(0.0095.0 2~0.0 2 Hz)、神经源性(0.0 2~0.0 5 Hz)、肌源性(0.0 5~0.15 Hz)、呼吸(0.15~0.4 Hz)、心脏(0.4~2 Hz)特征频率的复杂性。与65~75岁组相比，75~85岁组在基线(P<；0.05)和第二个高峰(P<；0.001)代谢性BFO的复杂性显著降低。与基线BFO相比，65-75岁组的受试者对局部加热的代谢性BFO的复杂性显著增加(P<；0.01)；而75-85岁组的受试者没有显著增加。我们的发现支持使用多重分形分析来评估与衰老相关的微血管功能障碍。
The objective of this study was to investigate the relationship between cutaneous vasodilatory function and nonlinear complexity of blood flow oscillations (BFO) in older people. A non-painful fast local heating protocol was applied to the sacral skin in 20 older subjects with various vasodilatory functions. Laser Doppler flowmetry was used to measure skin blood oscillations. The complexity of the characteristic frequencies (i.e., metabolic (0.0095–0.02 Hz), neurogenic (0.02–0.05 Hz), myogenic (0.05–0.15 Hz), respiratory (0.15–0.4 Hz), and cardiac (0.4–2 Hz)) of BFO was quantified using the multifractal detrended fluctuation analysis. Compared with the 65–75 years group, the complexity of metabolic BFO in the 75–85 years group was significantly lower at the baseline (P < 0.05) and the second peak (P < 0.001). Compared with baseline BFO, subjects in the 65–75 years group had a significant increase in the complexity of metabolic BFO (P < 0.01) in response to local heating; while subjects in the 75–85 years group did not. Our findings support the use of multifractal analysis to assess aging-related microvascular dysfunction.
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