Altered functional connectivity between hypothalamus and limbic system in fibromyalgia.
Altered functional connectivity between hypothalamus and limbic system in fibromyalgia.
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DOI：
10.1186/s13041-020-00705-2
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发表时间：
2021-01-20
期刊：
影响因子：
3.6
通讯作者：
Wang C
中科院分区：
文献类型：
--
作者：
Kong J;Huang Y;Liu J;Yu S;Ming C;Chen H;Wilson G;Harvey WF;Li W;Wang C
下丘脑连接神经系统和内分泌系统，在维持人体稳态方面发挥着至关重要的作用。本研究旨在探讨纤维肌痛患者下丘脑静息态功能连接（rsFC）的变化。招募了 24 名纤维肌痛患者和 24 名匹配的健康对照 (HC)。从纤维肌痛患者和 HC 中收集静息态 fMRI 数据。纤维肌痛患者在接受 12 周的太极身心干预后进行了第二次扫描。数据分析表明，与 HC 的功能连接相比，纤维肌痛患者的内侧下丘脑 (MH) rsFC 与丘脑和杏仁核的功能连接较少。太极身心干预后，纤维肌痛患者丘脑和杏仁核的 MH rsFC 增加，并伴有临床改善。有效的连通性分析显示，纤维肌痛患者的 MH 和丘脑相互作用受到破坏，这种相互作用可以通过身心锻炼而改变。我们的研究结果表明，纤维肌痛与间脑和边缘系统功能连接的改变有关。阐明间脑和边缘系统在纤维肌痛的病理生理学和发展中的作用可能有助于开发新的生物标志物和针对这种常见疾病的有效治疗方法。试验注册 ClinicalTrials.gov，NCT02407665。注册日期：2015 年 4 月 3 日，https://clinicaltrials.gov/ct2/show/NCT02407665?term=NCT02407665&draw=2&rank=1
The hypothalamus links the nervous system to the endocrine system and plays a crucial role in maintaining the human body's homeostasis. This study aims to investigate the resting state functional connectivity (rsFC) changes of the hypothalamus in fibromyalgia patients. 24 Fibromyalgia patients and 24 matched healthy controls (HCs) were recruited. Resting state fMRI data were collected from the fibromyalgia patients and HC’s. Fibromyalgia patients went through a second scan after 12 weeks of Tai Chi mind–body intervention. Data analysis showed that fibromyalgia patients displayed less medial hypothalamus (MH) rsFC with the thalamus and amygdala when compared to the functional connectivity in the HCs. After the Tai Chi mind–body intervention, fibromyalgia patients showed increased MH rsFC with the thalamus and amygdala accompanied by clinical improvement. Effective connectivity analysis showed disrupted MH and thalamus interaction in the fibromyalgia patients, which was altered by mind–body exercise. Our findings suggest that fibromyalgia is associated with altered functional connectivity within the diencephalon and limbic system. Elucidating the roles of the diencephalon and limbic system in the pathophysiology and development of fibromyalgia may facilitate the development of a new biomarker and effective treatment methods for this prevalent disorder. Trial Registration ClinicalTrials.gov, NCT02407665. Registered: 3 April 2015, https://clinicaltrials.gov/ct2/show/NCT02407665?term=NCT02407665&draw=2&rank=1
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