Evaluation of diagnostic performance of whole-body simultaneous PET/MRI in pediatric lymphoma.
Evaluation of diagnostic performance of whole-body simultaneous PET/MRI in pediatric lymphoma.
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DOI：
10.1007/s00247-016-3601-3
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发表时间：
2016-08
影响因子：
2.3
通讯作者：
Khanna G
中科院分区：
文献类型：
--
作者：
Ponisio MR;McConathy J;Laforest R;Khanna G
全身18F-氟脱氧葡萄糖（FDG）正电子发射断层扫描/计算机断层扫描（PET/CT）是淋巴瘤的标准治疗。同步PET/MRI（磁共振成像）是一种很有前途的新模式，它将PET的代谢信息与MRI的上级软组织分辨率和功能成像能力相结合，同时降低辐射剂量。关于PET/MRI在儿科环境中的临床性能的信息有限。本研究评价了与PET/CT相比，同时全身FDG-PET/MRI在淋巴瘤儿童中的可行性、剂量学以及定性和定量诊断性能。前瞻性招募接受标准护理FDG-PET/CT的淋巴瘤儿童，在PET/CT后立即进行PET/MRI。评价图像质量、病变检出和FDG摄取的解剖定位。PET/MRI和PET/CT测量正常器官的最大和平均标准化摄取值（SUVmax/平均值）以及大多数FDG-avid病变的SUVmax。辐射暴露的估计是使用特定的年龄相关因素计算的。对8名患者（平均年龄：15.3岁）进行了9次PET/MRI扫描。PET/CT和PET/MRI之间的平均时间间隔为51±10 min。PET/CT和PET/MRI检查均具有良好的图像质量和对齐，反应评估完全一致（9/9）。PET/MRI和PET/CT的SUV与正常器官高度相关（SUV平均r2：0.88，P<0.0001），与FDG-avid病变高度相关（SUV最大r2：0.94，P=0.0002）。与PET/CT相比，PET/MRI显示辐射暴露平均减少39% ± 13%。同时全身PET/MRI在儿科淋巴瘤中具有临床可行性。PET/MRI在病变检测和SUV测量方面的性能与PET/CT相当。用PET/MRI替代PET/CT可以显著降低儿童诊断成像的辐射剂量。
Whole-body 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) is the standard of care for lymphoma. Simultaneous PET/MRI (magnetic resonance imaging) is a promising new modality that combines the metabolic information of PET with superior soft-tissue resolution and functional imaging capabilities of MRI while decreasing radiation dose. There is limited information on the clinical performance of PET/MRI in the pediatric setting. This study evaluated the feasibility, dosimetry, and qualitative and quantitative diagnostic performance of simultaneous whole-body FDG-PET/MRI in children with lymphoma compared to PET/CT. Children with lymphoma undergoing standard of care FDG-PET/CT were prospectively recruited for PET/MRI performed immediately after the PET/CT. Images were evaluated for quality, lesion detection and anatomical localization of FDG uptake. Maximum and mean standardized uptake values (SUVmax/mean) of normal organs and SUVmax of the most FDG-avid lesions were measured for PET/MRI and PET/CT. Estimation of radiation exposure was calculated using specific age-related factors. Nine PET/MRI scans were performed in eight patients (mean age: 15.3 years). The mean time interval between PET/CT and PET/MRI was 51±10 min. Both the PET/CT and PET/MRI exams had good image quality and alignment with complete (9/9) concordance in response assessment. The SUVs from PET/MRI and PET/CT were highly correlated for normal organs (SUVmean r2: 0.88, P<0.0001) and very highly for FDG-avid lesions (SUVmax r2: 0.94, P=0.0002). PET/MRI demonstrated an average percent radiation exposure reduction of 39 % ± 13% compared with PET/CT. Simultaneous whole-body PET/MRI is clinically feasible in pediatric lymphoma. PET/MRI performance is comparable to PET/CT for lesion detection and SUV measurements. Replacement of PET/CT with PET/MRI can significantly decrease radiation dose from diagnostic imaging in children.
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DOI：
10.2214/ajr.14.13181
发表时间：
2015-04
期刊：
AJR. American journal of roentgenology
影响因子：
--
作者：
Heacock L;Weissbrot J;Raad R;Campbell N;Friedman KP;Ponzo F;Chandarana H
通讯作者：
Chandarana H
影响因子：
4.4
作者：
Kwee, Thomas C.;Vermoolen, Malou A.;Nievelstein, Rutger A. J.
通讯作者：
Nievelstein, Rutger A. J.
影响因子：
3.3
作者：
Heusch, Philipp;Buchbender, Christian;Heusner, Till A.
通讯作者：
Heusner, Till A.
影响因子：
9.3
作者：
Martinez-Moeller, Axel;Souvatzoglou, Michael;Nekolla, Stephan G.
通讯作者：
Nekolla, Stephan G.
影响因子：
5.9
作者：
Littooij, Annemieke S.;Kwee, Thomas C.;Nievelstein, Rutger A. J.
通讯作者：
Nievelstein, Rutger A. J.