Evidence for cardiomyocyte renewal in humans.
Evidence for cardiomyocyte renewal in humans.
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DOI：
10.1126/science.1164680
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发表时间：
2009-04-03
期刊：
影响因子：
--
通讯作者：
Frisén J
中科院分区：
文献类型：
--
作者：
Bergmann O;Bhardwaj RD;Bernard S;Zdunek S;Barnabé-Heider F;Walsh S;Zupicich J;Alkass K;Buchholz BA;Druid H;Jovinge S;Frisén J
很难确定我们是否仅限于我们出生时的心肌细胞，或者心肌细胞是否也在以后的生活中产生。我们利用冷战期间核弹试验产生的14C整合到DNA中来确定人类心肌细胞的年龄。我们报告说，心肌细胞更新，从20岁时的每年1%的周转率逐渐下降到75岁时的0.3%。不到50%的心肌细胞在正常寿命期间被交换。在成人心脏中产生心肌细胞的能力表明，努力开发旨在刺激心脏病理学中这一过程的治疗策略可能是合理的。
It has been difficult to establish whether we are limited to the heart muscle cells we are born with or if cardiomyocytes are generated also later in life. We have taken advantage of the integration of 14C, generated by nuclear bomb tests during the Cold War, into DNA to establish the age of cardiomyocytes in humans. We report that cardiomyocytes renew, with a gradual decrease from 1% turning over annually at the age of 20 to 0.3% at the age of 75. Less than 50% of cardiomyocytes are exchanged during a normal lifespan. The capacity to generate cardiomyocytes in the adult human heart suggests that it may be rational to work towards the development of therapeutic strategies aiming to stimulate this process in cardiac pathologies.
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