The role of oxidative stress in cerebral aneurysm formation and rupture.
The role of oxidative stress in cerebral aneurysm formation and rupture.
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DOI：
10.2174/15672026113109990003
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发表时间：
2013-08
影响因子：
2.1
通讯作者：
Dumont AS
中科院分区：
文献类型：
--
作者：
Starke RM;Chalouhi N;Ali MS;Jabbour PM;Tjoumakaris SI;Gonzalez LF;Rosenwasser RH;Koch WJ;Dumont AS
已知氧化应激会促进脑血管疾病的进展。此外，氧化应激可能会增加，但也增加炎症，脑动脉瘤发展和破裂的关键因素。氧化应激可诱导导致脑动脉瘤形成的重要过程，包括直接内皮损伤以及平滑肌细胞表型转变为炎性表型并最终凋亡。氧化应激通过上调趋化性细胞因子和粘附分子导致炎性细胞的募集和侵袭。基质金属蛋白酶可被自由基激活，导致血管壁重塑和破坏。自由基介导脂质过氧化，导致动脉粥样硬化，并有助于血液动力学应激和高血压病理，所有脑动脉瘤发展的组成部分。初步研究表明，针对氧化应激的疗法可能为脑动脉瘤提供未来的有益治疗，但进一步的研究表明，自由基在脑动脉瘤形成和破裂中的作用。这篇综述的目的是评估氧化应激在脑动脉瘤发病机制中的作用。
Oxidative stress is known to contribute to the progression of cerebrovascular disease. Additionally, oxidative stress may be increased by, but also augment inflammation, a key contributor to cerebral aneurysm development and rupture. Oxidative stress can induce important processes leading to cerebral aneurysm formation including direct endothelial injury as well as smooth muscle cell phenotypic switching to an inflammatory phenotype and ultimately apoptosis. Oxidative stress leads to recruitment and invasion of inflammatory cells through upregulation of chemotactic cytokines and adhesion molecules. Matrix metalloproteinases can be activated by free radicals leading to vessel wall remodeling and breakdown. Free radicals mediate lipid peroxidation leading to atherosclerosis and contribute to hemodynamic stress and hypertensive pathology, all integral elements of cerebral aneurysm development. Preliminary studies suggest that therapies targeted at oxidative stress may provide a future beneficial treatment for cerebral aneurysms, but further studies are indicated to define the role of free radicals in cerebral aneurysm formation and rupture. The goal of this review is to assess the role of oxidative stress in cerebral aneurysm pathogenesis.
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影响因子：
13.6
作者：
Dobrian, Anca D.;Lieb, David C.;Cole, Banumathi K.;Taylor-Fishwick, David A.;Chakrabarti, Swarup K.;Nadler, Jerry L.
通讯作者：
Nadler, Jerry L.
影响因子：
4.6
作者：
Chalouhi N;Ali MS;Starke RM;Jabbour PM;Tjoumakaris SI;Gonzalez LF;Rosenwasser RH;Koch WJ;Dumont AS
通讯作者：
Dumont AS
影响因子：
37.8
作者：
Fennessy, FM;Moneley, DS;Bouchier-Hayes, DJ
通讯作者：
Bouchier-Hayes, DJ
影响因子：
4.2
作者：
Brooks, PJ
通讯作者：
Brooks, PJ
影响因子：
8.3
作者：
Aoki, Tomohiro;Kataoka, Hiroharu;Hashimoto, Nobuo
通讯作者：
Hashimoto, Nobuo