Synthesis and biological activities of 1H-indole-1-carboxylic acid aryl esters as a marine antifouling coating
Synthesis and biological activities of 1H-indole-1-carboxylic acid aryl esters as a marine antifouling coating
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1H-吲哚-1-羧酸芳基酯海洋防污涂料的合成及生物活性
DOI：
10.1007/s11998-019-00305-3
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发表时间：
2020-01
期刊：
影响因子：
--
通讯作者：
Jianxin Yang
中科院分区：
文献类型：
--
作者：
Xuemei Wang;Xuan Wang;Miao Dong;Zhiming Li;Zhongxin Liu;Juyou Lu;Qiang Lin;Jianxin Yang
以吲哚和取代酚为原料，合成了一系列吲哚-1-羧酸芳基酯。通过IR和1H-NMR对目标化合物的结构进行了验证。研究了目标化合物的抑菌活性及其对海洋污染生物的抑制作用。结果表明，目标化合物对galbana、Platymonas subcorformis和Navicula三种海藻的生长均有显著的抑制作用，对藤壶幼虫的存活也有良好的抑制作用。取代基构效关系揭示了对生物抑制活性的显著影响：吸电子基取代的化合物比供电子基取代的化合物具有更大的生物活性。防污剂的释放率和海洋现场试验表明，最终化合物对海洋污染生物具有良好的防污效能。
A series of indole-1-carboxylic acid aryl esters was synthesized with indole and substituted phenols as raw materials. The structures of the target compounds were validated by IR and 1H-NMR spectroscopies. The inhibitory activities of the target compounds and their potencies against marine fouling organisms were investigated. The results showed that the target compounds had significant inhibitory effects on the growth of three seaweeds: Isochrysis galbana, Platymonas subcordiformis, and Navicula, and the target compounds also had excellent inhibition on the survival of barnacle larvae. The substituent structure–activity relationships revealed a significant effect on biological inhibition activity: Compounds substituted by electron-withdrawing groups had greater bioactivities than those containing electron-donating groups. Release rate of antifoulant and marine field tests indicated the final compounds had an outstanding antifouling potency against marine fouling organisms.
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影响因子：
8.7
作者：
Gipperth, Lena
通讯作者：
Gipperth, Lena
影响因子：
6.6
作者：
Carteau, David;Vallee-Rehel, Karine;Fay, Fabienne
通讯作者：
Fay, Fabienne
DOI：
10.1021/jo7013142
发表时间：
2007-10
期刊：
The Journal of organic chemistry
影响因子：
--
作者：
A. Tsotinis;A. Eleutheriades;L. D. Bari;G. Pescitelli
通讯作者：
A. Tsotinis;A. Eleutheriades;L. D. Bari;G. Pescitelli
在结构上与多奈哌齐相关的新吲哚衍生物的合成及其作为乙酰胆碱酯酶抑制剂的生物学评估。
DOI：
10.3390/molecules17054811
发表时间：
2012-04-25
期刊：
Molecules (Basel, Switzerland)
影响因子：
--
作者：
Ismail MM;Kamel MM;Mohamed LW;Faggal SI
通讯作者：
Faggal SI
影响因子：
2.3
作者：
D. Berto;R. B. Brusà;F. Cacciatore;S. Covelli;F. Rampazzo;O. Giovanardi;M. Giani
通讯作者：
D. Berto;R. B. Brusà;F. Cacciatore;S. Covelli;F. Rampazzo;O. Giovanardi;M. Giani