The potential utility of fecal (or intestinal) microbiota transplantation in controlling infectious diseases.
The potential utility of fecal (or intestinal) microbiota transplantation in controlling infectious diseases.
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粪便（或肠道）微生物群移植在控制传染病中的潜在效用。
DOI：
10.1080/19490976.2022.2038856
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发表时间：
2022-01
期刊：
影响因子：
12.2
通讯作者：
Marchesi JR
中科院分区：
文献类型：
--
作者：
Ghani R;Mullish BH;Roberts LA;Davies FJ;Marchesi JR
肠道微生物群被认为在防御感染中发挥作用，但反过来也充当潜在致病生物的储存库。微生物组的破坏会增加这些微生物的侵入性感染风险;因此，恢复肠道微生物群组成的策略是减轻这种风险的关键策略。粪便（或肠道）微生物群移植（FMT/IMT）是向受影响的受体施用最低限度操作的筛选的健康供体粪便，并且目前仍然是主要的“全微生物群”治疗方法。在使用FMT治疗复发性艰难梭菌感染的显著成功的驱动下，FMT在治疗其他感染性疾病中的潜在用途是一个活跃的研究领域。在这篇综述中，我们讨论了这种治疗的关键例子，基于最近的研究结果，有关微生物群和感染之间的相互作用，以及FMT/IMT的潜在进一步开发。
The intestinal microbiota is recognized to play a role in the defense against infection, but conversely also acts as a reservoir for potentially pathogenic organisms. Disruption to the microbiome can increase the risk of invasive infection from these organisms; therefore, strategies to restore the composition of the gut microbiota are a potential strategy of key interest to mitigate this risk. Fecal (or Intestinal) Microbiota Transplantation (FMT/IMT), is the administration of minimally manipulated screened healthy donor stool to an affected recipient, and remains the major ‘whole microbiome’ therapeutic approach at present. Driven by the marked success of using FMT in the treatment of recurrent Clostridioides difficile infection, the potential use of FMT in treating other infectious diseases is an area of active research. In this review, we discuss key examples of this treatment based on recent findings relating to the interplay between microbiota and infection, and potential further exploitations of FMT/IMT.
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DOI：
10.1016/j.lanepe.2021.100181
发表时间：
2021-10
期刊：
The Lancet regional health. Europe
影响因子：
--
作者：
Baunwall SMD;Terveer EM;Dahlerup JF;Erikstrup C;Arkkila P;Vehreschild MJ;Ianiro G;Gasbarrini A;Sokol H;Kump PK;Satokari R;De Looze D;Vermeire S;Nakov R;Brezina J;Helms M;Kjeldsen J;Rode AA;Kousgaard SJ;Alric L;Trang-Poisson C;Scanzi J;Link A;Stallmach A;Kupcinskas J;Johnsen PH;Garborg K;Rodríguez ES;Serrander L;Brummer RJ;Galpérine KT;Goldenberg SD;Mullish BH;Williams HR;Iqbal TH;Ponsioen C;Kuijper EJ;Cammarota G;Keller JJ;Hvas CL
通讯作者：
Hvas CL
影响因子：
5.1
作者：
Bajaj JS;Shamsaddini A;Fagan A;Sterling RK;Gavis E;Khoruts A;Fuchs M;Lee H;Sikaroodi M;Gillevet PM
通讯作者：
Gillevet PM
影响因子：
3.5
作者：
Cattaneo, C.;Di Blasi, R.;Pagano, L.
通讯作者：
Pagano, L.
影响因子：
16.6
作者：
Burrello, Claudia;Garavaglia, Federica;Facciotti, Federica
通讯作者：
Facciotti, Federica
影响因子：
1.9
作者：
Bahl, Martin Iain;Jorgensen, Simon Mark Dahl;Hvas, Christian Lodberg
通讯作者：
Hvas, Christian Lodberg