Highly pathogenic coronaviruses and the kidney.
Highly pathogenic coronaviruses and the kidney.
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DOI：
10.1016/j.biopha.2022.113807
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发表时间：
2022-12
期刊：
影响因子：
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中科院分区：
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自2019年底以来，严重急性呼吸综合征冠状病毒2型(SARS-CoV-2)的爆发引发了肺炎疫情，对全球236个国家、地区和地区的公共卫生构成重大挑战。临床上，除了肺部感染的症状外，许多SARS-CoV-2感染的患者，特别是危重患者，最终会发展成多器官衰竭，其中肾功能损害是常见的，最终导致死亡率和发病率增加等严重后果。到目前为止，已有三种冠状病毒引发了全球重大公共卫生安全事件：严重急性呼吸综合征冠状病毒(SARS-CoV)、中东呼吸综合征冠状病毒(MERS-CoV)和SARS-CoV-2。在冠状病毒引起的疾病中，冠状病毒病2019(新冠肺炎)影响最大，危害最大。与SARS-CoV-2感染类似，先前的研究表明，肾脏损伤在另外两种高致病性冠状病毒患者中也很常见和突出。因此，本综述旨在全面总结这三起大流行级别感染的流行病学和临床特点，深入分析新冠肺炎在各类肾脏疾病中的可能机制，探讨SARS-CoV-2继发性肾脏疾病的病因，为进一步研究和临床预防冠状病毒引起的肾脏损害提供参考。
Since the end of 2019, the outbreak of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has triggered a pneumonia epidemic, posing a significant public health challenge in 236 countries, territories, and regions worldwide. Clinically, in addition to the symptoms of pulmonary infection, many patients with SARS-CoV-2 infections, especially those with a critical illness, eventually develop multiple organ failure in which damage to the kidney function is common, ultimately leading to severe consequences such as increased mortality and morbidity. To date, three coronaviruses have set off major global public health security incidents: Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV), Middle East Respiratory Syndrome Coronavirus (MERS-CoV), and SARS-CoV-2. Among the diseases caused by the coronaviruses, the coronavirus disease 2019 (COVID-19) has been the most impactful and harmful. Similar to with SARS-CoV-2 infections, previous studies have shown that kidney injury is also common and prominent in patients with the two other highly pathogenic coronaviruses. Therefore, in this review, we aimed to comprehensively summarize the epidemiological and clinical characteristics of these three pandemic-level infections, provide a deep analysis of the potential mechanism of COVID-19 in various types of kidney diseases, and explore the causes of secondary kidney diseases of SARS-CoV-2, so as to provide a reference for further research and the clinical prevention of kidney damage caused by coronaviruses.
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发表时间：
2021-05
期刊：
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology
影响因子：
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作者：
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影响因子：
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