Fluoride-activated photothermal system for promoting bacteria-infected wound healing.
Fluoride-activated photothermal system for promoting bacteria-infected wound healing.
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DOI：
10.1186/s12951-023-02091-y
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发表时间：
2023-09-15
影响因子：
10.2
通讯作者：
Feng, Guangfu
中科院分区：
文献类型：
--
作者：
Du, Yuanchun;Liu, Zekai;Yang, Qingxin;Zhen, Deshuai;Liu, Yu;Feng, Guangfu
虽然采用纳米酶的光热疗法（PTT）已显示出优异的抗菌潜力，但过度加热通常会损害宿主细胞并阻碍恢复。在此，我们报告了一种创新的技术，用于通过管理纳米酶的催化活性来获取程序化温度。CeO 2 + F− + TMB的光热系统可以在近红外照射下通过调节氟离子的浓度来获得精确的光热温度。在优化的光热温度下，该光热系统可提供良好的光热抗菌处理，对金黄色葡萄球菌和大肠杆菌具有高效的体外抗菌效果。体内伤口愈合实验证实，该系统能有效促进成纤维细胞增殖、血管生成和胶原沉积，具有显著的伤口愈合效率。这一策略为创造新一代PTT提供了一种新的设计理念，并为创造替代抗生素开辟了道路。在线版本包含补充材料，可通过10.1186/s12951-023-02091-y获得。
Although photothermal therapy (PTT) employing nanozymes has shown excellent antibacterial potential, excessive heating generally harms host cells and hinders recovery. Herein, we report an innovative technique for acquiring the programmed temperature by managing the catalytic activity of nanozymes. The photothermal system of CeO2 + F− + TMB can obtain precise photothermal temperature by adjusting the concentration of fluoride ions under near-infrared irradiation. At the optimized photothermal temperature, the photothermal system affords fine photothermal antibacterial treatment with high-efficiency antibacterial effects against Staphylococcus aureus and Escherichia coli in vitro. In vivo wound healing experiments confirm that the system can effectively promote fibroblast proliferation, angiogenesis and collagen deposition with remarkable wound healing efficiency. This strategy offers a novel design concept for creating a new generation of PTT and opens the way for the creation of alternative antibiotics. The online version contains supplementary material available at 10.1186/s12951-023-02091-y.
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