POD Nanozyme optimized by charge separation engineering for light/pH activated bacteria catalytic/photodynamic therapy.
POD Nanozyme optimized by charge separation engineering for light/pH activated bacteria catalytic/photodynamic therapy.
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经电荷分离工程优化的POD纳米酶用于光/pH活化细菌催化/光动力治疗。
DOI：
10.1038/s41392-022-00900-8
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发表时间：
2022-03-28
影响因子：
39.3
通讯作者：
Zhao Y
中科院分区：
文献类型：
--
作者：
Cao C;Zhang T;Yang N;Niu X;Zhou Z;Wang J;Yang D;Chen P;Zhong L;Dong X;Zhao Y
目前纳米催化剂在临床抗感染治疗中的可行性，特别是对于耐药菌感染，由于活性氧产生不足而受到极大的限制。本文采用溶剂热反应和光还原法合成了一种新型的Ag/Bi 2 MoO 6（Ag/BMO）纳米酶，该纳米酶通过电荷分离工程优化，具有光活化的可持续的过氧化物酶模拟活性和近红外II光动力学性能。Ag/BMO纳米酶对耐甲氧西林金黄色葡萄球菌（MRSA）具有良好的杀菌性能（~99.9%）。Ag/BMO纳米粒子的优异抗菌性能归因于过氧化物酶样活性、NIR-Ⅱ光动力学行为和酸性增强的Ag+释放。正如理论计算所揭示的那样，将Ag引入BMO使得更容易分离用于ROS产生的光触发电子-空穴对。Ag/BMO纳米粒子的导带和价带电位有利于O2还原为·O2−。在1064 nm激光照射下，电子向BMO的转移有利于Mo 5 +/Mo 6+的可逆变化，进一步提高了基于Russell机理的类过氧化物酶催化活性和NIR-Ⅱ光动力学性能。在体内，Ag/BMO NPs对MRSA感染的伤口表现出有希望的治疗效果。本研究丰富了纳米酶的研究，证明了纳米酶可以通过电荷分离工程策略进行合理优化。
The current feasibility of nanocatalysts in clinical anti-infection therapy, especially for drug-resistant bacteria infection is extremely restrained because of the insufficient reactive oxygen generation. Herein, a novel Ag/Bi2MoO6 (Ag/BMO) nanozyme optimized by charge separation engineering with photoactivated sustainable peroxidase-mimicking activities and NIR-II photodynamic performance was synthesized by solvothermal reaction and photoreduction. The Ag/BMO nanozyme held satisfactory bactericidal performance against methicillin-resistant Staphylococcus aureus (MRSA) (~99.9%). The excellent antibacterial performance of Ag/BMO NPs was ascribed to the corporation of peroxidase-like activity, NIR-II photodynamic behavior, and acidity-enhanced release of Ag+. As revealed by theoretical calculations, the introduction of Ag to BMO made it easier to separate photo-triggered electron-hole pairs for ROS production. And the conduction and valence band potentials of Ag/BMO NPs were favorable for the reduction of O2 to ·O2−. Under 1064 nm laser irradiation, the electron transfer to BMO was beneficial to the reversible change of Mo5+/Mo6+, further improving the peroxidase-like catalytic activity and NIR-II photodynamic performance based on the Russell mechanism. In vivo, the Ag/BMO NPs exhibited promising therapeutic effects towards MRSA-infected wounds. This study enriches the nanozyme research and proves that nanozymes can be rationally optimized by charge separation engineering strategy.
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影响因子：
13.3
作者：
Cao, Changyu;Ge, Wei;Dong, Xiaochen
通讯作者：
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影响因子：
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作者：
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影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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