Suppression of signal transducer and activator of transcription 3-dependent B lymphocyte terminal differentiation by BCL-6.
Suppression of signal transducer and activator of transcription 3-dependent B lymphocyte terminal differentiation by BCL-6.
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DOI：
10.1084/jem.192.12.1841
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发表时间：
2000-12-18
期刊：
影响因子：
--
通讯作者：
Fearon DT
中科院分区：
文献类型：
--
作者：
Reljic R;Wagner SD;Peakman LJ;Fearon DT
淋巴细胞通常在抗原暴露后数天内分化为效应细胞，但在生发中心，由于体细胞超突变产生高亲和力抗体突变，最终分化延迟。在这里，我们研究了BCL-6是否可以介导末端分化的阻止，BCL-6是生发中心B细胞表达的一种转录抑制因子，是B细胞发育的这一阶段所必需的。我们发现BCL-6通过抑制浆细胞发育的主要调节因子B淋巴细胞诱导成熟蛋白（Blimp-1）的信号转导和转录激活因子3依赖表达，抑制转化和原代B细胞向浆细胞的分化。BCL-6作为B淋巴细胞分化抑制因子的这种功能也可能是其基因染色体易位与B细胞淋巴瘤之间关联的基础。
Lymphocytes usually differentiate into effector cells within days after antigen exposure, except in germinal centers where terminal differentiation is delayed while somatic hypermutation creates high-affinity antibody mutants. Here we investigate whether arrest of terminal differentiation can be mediated by BCL-6, a transcriptional repressor that is expressed by germinal center B cells and is required for this phase of B cell development. We find that BCL-6 suppresses the differentiation of transformed and primary B cells to plasma cells by inhibiting the signal transducer and activator of transcription 3–dependent expression of the major regulator of plasma cell development, the B lymphocyte–induced maturation protein (Blimp-1). This function of BCL-6 as a repressor of B lymphocyte differentiation may also underlie the association between chromosomal translocations of its gene and B cell lymphomas.
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影响因子：
30.8
作者：
Ye, BH;Cattoretti, G;DallaFavera, R
通讯作者：
DallaFavera, R
影响因子：
56.9
作者：
Lin, Y;Wong, KK;Calame, K
通讯作者：
Calame, K
影响因子：
64.5
作者：
BEREK, C;BERGER, A;APEL, M
通讯作者：
APEL, M
影响因子：
64.5
作者：
BLACKMAN, MA;TIGGES, MA;KOSHLAND, ME
通讯作者：
KOSHLAND, ME
DOI：
10.1073/pnas.90.18.8392
发表时间：
1993-09-15
影响因子：
11.1
作者：
PEAR, WS;NOLAN, GP;BALTIMORE, D
通讯作者：
BALTIMORE, D