Exploiting molecular mimicry to broaden the immune response to carbohydrate antigens for vaccine development.
Exploiting molecular mimicry to broaden the immune response to carbohydrate antigens for vaccine development.
复制标题
利用分子拟态来扩大对碳水化合物抗原的免疫反应,用于疫苗开发。
DOI:
10.1016/s0264-410x(00)00527-2
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发表时间:
2001
期刊:
影响因子:
5.5
通讯作者:
Kieber-Emmons,T
中科院分区:
文献类型:
--
作者:
Cunto-Amesty,G;Luo,P;Monzavi-Karbassi,B;Lees,A;Kieber-Emmons,T
Peptide mimetics of carbohydrates represent an alternative approach to induce anti-carbohydrate responses. Depending on their formulation, peptide mimetics can mediate T-independent or T-dependent responses. Multivalent peptide mimeotopes can induce high IgM/IgG ratios, as non-conjugated carbohydrates do. Here we observe that immunization with multivalent peptide mimeotope conjugated to BSA enhances carbohydrate reactive antibodies in Balb/c mice and xid mice, with IgG1 greater than IgG2a, in xid mice. These results suggest that mimeotope-conjugate formulations might augment carbohydrate-specific immune responses in immuno-compromised hosts.
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DOI:
10.1200/jco.2000.18.2.376
发表时间:
2000
期刊:
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
影响因子:
--
作者:
K. Foon;J. Lutzky;R. Baral;J. Yannelli;L. Hutchins;A. Teitelbaum;O. Kashala;Ruma Das;Juanita Garrison;R. Reisfeld;M. Bhattacharya‐Chatterjee
通讯作者:
K. Foon;J. Lutzky;R. Baral;J. Yannelli;L. Hutchins;A. Teitelbaum;O. Kashala;Ruma Das;Juanita Garrison;R. Reisfeld;M. Bhattacharya‐Chatterjee
DOI:
10.1093/infdis/173.4.1014
发表时间:
1996
期刊:
The Journal of infectious diseases
影响因子:
--
作者:
D. Powers;E. Anderson;Kathleen R. Lottenbach;C. Mink
通讯作者:
C. Mink
DOI:
10.1093/infdis/161.5.821
发表时间:
1990
期刊:
The Journal of infectious diseases
影响因子:
--
作者:
J. Robbins;R. Schneerson
通讯作者:
R. Schneerson
影响因子:
56.9
作者:
CASTANO, AR;TANGRI, S;PETERSON, PA
通讯作者:
PETERSON, PA
影响因子:
46.9
作者:
Agadjanyan, M;Luo, P;KieberEmmons, T
通讯作者:
KieberEmmons, T