Do galectins play a role in venous thrombosis? a review.
Do galectins play a role in venous thrombosis? a review.
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DOI：
10.1016/j.thromres.2009.11.011
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发表时间：
2010-05
影响因子：
7.5
通讯作者：
Wakefield TW
中科院分区：
文献类型：
--
作者：
Diaz JA;Ramacciotti E;Wakefield TW
半乳糖凝集素是碳水化合物结合蛋白家族，与细胞表面的半乳糖苷和细胞外糖蛋白具有高亲和力。它们参与多种生物学功能，包括调节细胞凋亡、细胞活化和炎症。我们的实验室最近发现，与阴性对照相比，在深静脉血栓 (DVT) 患者的微粒蛋白质组学分析中，半乳糖凝集素 3 结合蛋白 (Gal-3BP) 表达上调。 P-选择素是另一种参与血栓传播的糖蛋白，已被证明是 DVT 治疗的一个有前景的靶标，并已被我们小组广泛研究。半乳糖凝集素参与 P-选择素的表达，并可能参与静脉血栓形成过程。本手稿回顾了半乳糖凝集素的功能、它们在炎症和血栓形成中的作用以及它们作为 DVT 治疗新药理学靶点的潜在影响。
Galectins are a family of carbohydrate-binding proteins that have a high affinity to galactosides on cell surfaces and extra cellular glycoproteins. They are involved in a variety of biological functions, including modulation of cell apoptosis, cell activation and inflammation. Our laboratory has recently identified galectin-3 binding protein (Gal-3BP) as being up-regulated in a microparticle proteomics analysis for deep venous thrombosis (DVT) patients compared to negative controls. P-selectin, another glycoprotein involved in thrombus propagation, has proven a promising target for DVT management and has been widely studied by our group. Galectins are involved in P-selectin expression and can potentially be implicated in the venous thrombogenesis process. The function of galectins, their role in inflammation and thrombosis as well as their potential implications as a new pharmacological target for DVT management are reviewed in this manuscript.
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影响因子：
4.3
作者：
Eude-Le Parco, Isabelle;Gendronneau, Gaelle;Poirier, Francoise
通讯作者：
Poirier, Francoise
影响因子：
4.3
作者：
Myers, Daniel D., Jr.;Henke, Peter K.;Wakefield, Thomas W.
通讯作者：
Wakefield, Thomas W.
DOI：
10.1016/j.bbrc.2008.12.153
发表时间：
2009-02-06
影响因子：
3.1
作者：
Lin, Chi-Iou;Whang, Edward E.;Ruan, Daniel T.
通讯作者：
Ruan, Daniel T.
影响因子：
2
作者：
Horstman, Lawrence L.;Jy, Wenche;Ahn, Yeon S.
通讯作者：
Ahn, Yeon S.
影响因子：
6.7
作者：
Meier, Thomas R.;Myers, Daniel D., Jr.;Wakefield, Thomas W.
通讯作者：
Wakefield, Thomas W.