CNS activation and regional connectivity during pantomime observation: no engagement of the mirror neuron system for deaf signers.
CNS activation and regional connectivity during pantomime observation: no engagement of the mirror neuron system for deaf signers.
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DOI：
10.1016/j.neuroimage.2009.08.001
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发表时间：
2010-01-01
期刊：
影响因子：
5.7
通讯作者：
Braun, Allen
中科院分区：
文献类型：
--
作者：
Emmorey, Karen;Xu, Jiang;Gannon, Patrick;Goldin-Meadow, Susan;Braun, Allen
聋人手语者有丰富的经验使用他们的手来沟通。使用功能磁共振成像，我们研究了14名聋人手语和14名听力非手语的神经系统参与的感知过程中的手动通信。参与者被动地观看被屏蔽的哑剧视频片段（例如，剥一根想象的香蕉）和美国手语（ASL）中被非手语者评为无意义的动作动词（例如，舞）。与视觉固定相反，哑剧强烈激活额顶叶区（镜像神经元系统，MNS）的听力非签名者，但只有双边中颞区的聋人签名者。与美国手语动词相比，哑剧选择性地从事下，上级顶叶区听力非签名者，但右上级颞叶皮层聋人签名。手语动词的知觉招募类似的地区哑剧聋人签名，有证据表明，更多的参与左额下回的手语动词。左半球种子体素（腹侧前运动，顶下小叶，梭状回）的功能连接分析显示强大的连接与MNS的听力非签名者。聋人签名者表现出与右半球的功能连接，听力组的梭状回种子体素没有观察到。我们认为，终身经验与手动通信，和/或听觉剥夺，可能会改变区域连接和大脑激活时，观看哑剧。我们的结论是，缺乏激活内的MNS聋人签名不支持人类交流的帐户，依赖于自动感觉和行动之间的共鸣。
Deaf signers have extensive experience using their hands to communicate. Using fMRI, we examined the neural systems engaged during the perception of manual communication in 14 deaf signers and 14 hearing non-signers. Participants passively viewed blocked video clips of pantomimes (e.g., peeling an imaginary banana) and action verbs in American Sign Language (ASL) that were rated as meaningless by non-signers (e.g., TO-DANCE). In contrast to visual fixation, pantomimes strongly activated fronto-parietal regions (the mirror neuron system, MNS) in hearing non-signers, but only bilateral middle temporal regions in deaf signers. When contrasted with ASL verbs, pantomimes selectively engaged inferior and superior parietal regions in hearing non-signers, but right superior temporal cortex in deaf signers. The perception of ASL verbs recruited similar regions as pantomimes for deaf signers, with some evidence of greater involvement of left inferior frontal gyrus for ASL verbs. Functional connectivity analyses with left hemisphere seed voxels (ventral premotor, inferior parietal lobule, fusiform gyrus) revealed robust connectivity with the MNS for the hearing non-signers. Deaf signers exhibited functional connectivity with the right hemisphere that was not observed for the hearing group for the fusiform gyrus seed voxel. We suggest that life-long experience with manual communication, and/or auditory deprivation, may alter regional connectivity and brain activation when viewing pantomimes. We conclude that the lack of activation within the MNS for deaf signers does not support an account of human communication that depends upon automatic sensorimotor resonance between perception and action.
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