Activation of dopamine D1/D5 receptors facilitates the induction of presynaptic long‐term potentiation at hippocampal output synapses
Activation of dopamine D1/D5 receptors facilitates the induction of presynaptic long‐term potentiation at hippocampal output synapses
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多巴胺 D1/D5 受体的激活促进海马输出突触突触前长期增强的诱导
DOI：
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发表时间：
2010
影响因子：
3.4
通讯作者：
J. Behr
中科院分区：
文献类型：
--
作者：
E. Roggenhofer;P. Fidzinski;J. Bartsch;Felix T. Kurz;O. Shor;J. Behr
新信息的编码已经被提议依赖于在新奇检测期间海马结构中多巴胺的时间锁定释放。然而，海马体中新奇检测的位置仍然是一个有争议的问题。根据目前的模型，CA 1和下托作为新的感觉信息的检测器和分配器。虽然大多数CA 1锥体神经元表现出规则的尖峰行为，但大多数下托锥体神经元发出高频率的动作电位爆发。本研究探讨了多巴胺D1/D5受体激活促进大鼠CA 1规则尖峰和下托爆发尖峰锥体细胞中活性依赖性长时程增强（LTP）诱导的功效。使用弱刺激方案，设置在诱导LTP的亚阈值水平，我们表明，激活D1/D5受体5-10分钟有助于下托爆发尖峰神经元的LTP，但在CA 1神经元中则不然。 结果表明，D1/D5受体促进的LTP是NMDA受体依赖性的，并且需要蛋白激酶A的激活。此外，D1/D5受体促进的LTP被证明是突触前表达的，并依赖于突触前Ca 2+信号传导。多巴胺诱导的突触前NMDA受体依赖性LTP的易化现象在下托爆发-尖峰锥体细胞中与在该脑区域中新奇检测期间多巴胺的时间锁定释放的观察一致，并揭示了海马输出信息编码的有趣机制。
Encoding of novel information has been proposed to rely on the time‐locked release of dopamine in the hippocampal formation during novelty detection. However, the site of novelty detection in the hippocampus remains a matter of debate. According to current models, the CA1 and the subiculum act as detectors and distributors of novel sensory information. Although most CA1 pyramidal neurons exhibit regular‐spiking behavior, the majority of subicular pyramidal neurons fire high‐frequency bursts of action potentials. The present study investigates the efficacy of dopamine D1/D5 receptor activation to facilitate the induction of activity‐dependent long‐term potentiation (LTP) in rat CA1 regular‐spiking and subicular burst‐spiking pyramidal cells. Using a weak stimulation protocol, set at a level subthreshold for the induction of LTP, we show that activation of D1/D5 receptors for 5–10 min facilitates LTP in subicular burst‐spiking neurons but not in CA1 neurons. The results demonstrate that D1/D5 receptor‐facilitated LTP is NMDA receptor‐dependent, and requires the activation of protein kinase A. In addition, the D1/D5 receptor‐facilitated LTP is shown to be presynaptically expressed and relies on presynaptic Ca2+ signaling. The phenomenon of dopamine‐induced facilitation of presynaptic NMDA receptor‐dependent LTP in subicular burst‐spiking pyramidal cells is in accordance with observations of the time‐locked release of dopamine during novelty detection in this brain region, and reveals an intriguing mechanism for the encoding of hippocampal output information.
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影响因子：
2.5
作者：
Lezcano, N;Bergson, C
通讯作者：
Bergson, C
DOI：
10.1073/pnas.94.26.14859
发表时间：
1997-12-23
影响因子：
11.1
作者：
Blank, T;Nijholt, I;Spiess, J
通讯作者：
Spiess, J
DOI：
10.1073/pnas.92.7.2446
发表时间：
1995-03-28
影响因子：
11.1
作者：
HUANG, YY;KANDEL, ER
通讯作者：
KANDEL, ER
影响因子：
2.5
作者：
Cepeda, C;Colwell, CS;Levine, MS
通讯作者：
Levine, MS
海马点燃后两周，中脑边缘多巴胺受体增加。
影响因子：
2.9
作者：
Csernansky,JG;Kerr,S;Pruthi,R;Prosser,ES
通讯作者：
Prosser,ES