Insight into Extracellular Vesicle-Cell Communication: From Cell Recognition to Intracellular Fate.
Insight into Extracellular Vesicle-Cell Communication: From Cell Recognition to Intracellular Fate.
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DOI：
10.3390/cells11091375
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发表时间：
2022-04-19
期刊：
影响因子：
6
通讯作者：
Gil, Ziv
中科院分区：
文献类型：
--
作者：
Ginini, Lana;Billan, Salem;Fridman, Eran;Gil, Ziv
细胞外囊泡是由细胞分泌的异形脂双层膜结构。它们由凋亡小体、微泡和外来体组成，并携带一系列核酸和蛋白质，这些核酸和蛋白质是通过细胞表面上的相互作用进行细胞间通讯所必需的。它们启动细胞内信号传导途径或货物分子的转移，这在生理过程以及病理过程（如癌症）中在受体细胞中引起多效性应答。因此，重要的是要了解EV被吸收到细胞中的分子手段。因此，本文综述了EV靶向和摄取的潜在机制。EV进入的主要方法似乎是内吞作用，其中网格蛋白介导的、小窝依赖的、巨胞饮的、吞噬的和脂筏介导的摄取被各种描述为普遍存在。EV摄取机制可能取决于囊泡和靶细胞表面上发现的蛋白质和脂质。由于EV已被证明有助于癌症的生长和进展，因此进一步探索和靶向EV用于内化到肿瘤细胞中的通道可能有助于预防或减缓癌症发病机制。
Extracellular vesicles (EVs) are heterogamous lipid bilayer-enclosed membranous structures secreted by cells. They are comprised of apoptotic bodies, microvesicles, and exosomes, and carry a range of nucleic acids and proteins that are necessary for cell-to-cell communication via interaction on the cells surface. They initiate intracellular signaling pathways or the transference of cargo molecules, which elicit pleiotropic responses in recipient cells in physiological processes, as well as pathological processes, such as cancer. It is therefore important to understand the molecular means by which EVs are taken up into cells. Accordingly, this review summarizes the underlying mechanisms involved in EV targeting and uptake. The primary method of entry by EVs appears to be endocytosis, where clathrin-mediated, caveolae-dependent, macropinocytotic, phagocytotic, and lipid raft-mediated uptake have been variously described as being prevalent. EV uptake mechanisms may depend on proteins and lipids found on the surfaces of both vesicles and target cells. As EVs have been shown to contribute to cancer growth and progression, further exploration and targeting of the gateways utilized by EVs to internalize into tumor cells may assist in the prevention or deceleration of cancer pathogenesis.
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影响因子：
7.3
作者：
Andreu Z;Yáñez-Mó M
通讯作者：
Yáñez-Mó M
影响因子：
16.6
作者：
Bonsergent E;Grisard E;Buchrieser J;Schwartz O;Théry C;Lavieu G
通讯作者：
Lavieu G
间充质干细胞衍生的外泌体通过小胶质细胞/巨噬细胞促进大鼠创伤性脑损伤的恢复
DOI：
10.18632/aging.103692
发表时间：
2020-09-23
期刊：
Aging
影响因子：
--
作者：
Chen Y;Li J;Ma B;Li N;Wang S;Sun Z;Xue C;Han Q;Wei J;Zhao RC
通讯作者：
Zhao RC
DOI：
10.1016/j.nano.2017.03.001
发表时间：
2017-07-01
影响因子：
5.4
作者：
Agrawal, Ashish K.;Aqil, Farrukh;Gupta, Ramesh C.
通讯作者：
Gupta, Ramesh C.
影响因子：
12.6
作者：
Choi, Yonghyun;Park, Uiseon;Choi, Jonghoon
通讯作者：
Choi, Jonghoon