Association of biochemical markers with bone marrow lesion changes on imaging-data from the Foundation for the National Institutes of Health Osteoarthritis Biomarkers Consortium.
Association of biochemical markers with bone marrow lesion changes on imaging-data from the Foundation for the National Institutes of Health Osteoarthritis Biomarkers Consortium.
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生化标志物与骨髓病变变化的相关性--来自国立卫生研究院骨关节炎生物标志物联盟基金会的数据。
DOI：
10.1186/s13075-023-03253-x
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发表时间：
2024-01-18
影响因子：
4.9
通讯作者：
中科院分区：
文献类型：
--
作者：
评估24个月内膝关节骨关节炎（OA）MRI上与骨髓病变（BML）相关的生化标志物短期变化的预后价值，此外，评估与组织转换和炎症相关的生化标志物与MRI上BML之间的关系。分析了来自美国国立卫生研究院OA生物标志物联盟骨关节炎倡议基金会的数据（n = 600）。根据MRI骨关节炎膝关节评分（MOAKS）系统（0-3）测量15个膝关节亚区的BML。评估的血清和尿液生化标志物如下：血清I型胶原蛋白C末端交联端肽（CTX-I）、血清I型胶原蛋白N端肽（NTX-I）、尿CTX-Iα和CTX-Iβ、尿NTX-I、尿C末端交联端肽II型胶原蛋白（CTX-II）、血清基质金属蛋白酶（MMP）降解的I、II和III型胶原蛋白（C1 M、C2M、C3 M）、IIb型胶原的血清高敏感性前肽（hsPRO-C2）和基质金属蛋白酶产生的C-反应蛋白的新表位（CRPM）。使用针对协变量调整的回归模型检查了12个月内生化标志物变化与24个月内BML变化之间的相关性。检查了基线和24个月内C1 M、C2M、C3 M、hsPRO-C2和CRPM与BML之间的关系。12个月内血清CTX-I和尿CTX-Iβ升高与24个月时受任何BML影响的亚区数量变化的几率增加相关。hsPRO-C2的增加与24个月内受任何BML影响的子区域数量恶化的几率降低相关。C1 M和C3 M与基线时受影响的BML相关。血清CTX-I、hsPRO-C2和尿CTX-Iβ的短期变化可能是MRI显示的BML进展的预后指标。C1 M和C3 M与MRI基线BML的相关性值得进一步研究。
To assess the prognostic value of short-term change in biochemical markers as it relates to bone marrow lesions (BMLs) on MRI in knee osteoarthritis (OA) over 24 months and, furthermore, to assess the relationship between biochemical markers involved with tissue turnover and inflammation and BMLs on MRI. Data from the Foundation for the National Institutes of Health OA Biomarkers Consortium within the Osteoarthritis Initiative (n = 600) was analyzed. BMLs were measured according to the MRI Osteoarthritis Knee Score (MOAKS) system (0–3), in 15 knee subregions. Serum and urinary biochemical markers assessed were as follows: serum C-terminal crosslinked telopeptide of type I collagen (CTX-I), serum crosslinked N-telopeptide of type I collagen (NTX-I), urinary CTX-Iα and CTX-Iβ, urinary NTX-I, urinary C-terminal cross-linked telopeptide of type II collagen (CTX-II), serum matrix metalloproteinase (MMP)-degraded type I, II, and III collagen (C1M, C2M, C3M), serum high sensitivity propeptide of type IIb collagen (hsPRO-C2), and matrix metalloproteinase-generated neoepitope of C-reactive protein (CRPM). The association between change in biochemical markers over 12 months and BMLs over 24 months was examined using regression models adjusted for covariates. The relationship between C1M, C2M, C3M, hsPRO-C2, and CRPM and BMLs at baseline and over 24 months was examined. Increases in serum CTX-I and urinary CTX-Iβ over 12 months were associated with increased odds of changes in the number of subregions affected by any BML at 24 months. Increase in hsPRO-C2 was associated with decreased odds of worsening in the number of subregions affected by any BML over 24 months. C1M and C3M were associated with BMLs affected at baseline. Short-term changes in serum CTX-I, hsPRO-C2, and urinary CTX-Iβ hold the potential to be prognostic of BML progression on MRI. The association of C1M and C3M with baseline BMLs on MRI warrants further investigation.
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DOI：
10.1002/art.40527
发表时间：
2018-09
期刊：
Arthritis & rheumatology (Hoboken, N.J.)
影响因子：
--
作者：
Kjelgaard-Petersen CF;Platt A;Braddock M;Jenkins MA;Musa K;Graham E;Gantzel T;Slynn G;Weinblatt ME;Karsdal MA;Thudium CS;Bay-Jensen AC
通讯作者：
Bay-Jensen AC
DOI：
10.1002/art.39731
发表时间：
2016-10
期刊：
Arthritis & rheumatology (Hoboken, N.J.)
影响因子：
--
作者：
Collins JE;Losina E;Nevitt MC;Roemer FW;Guermazi A;Lynch JA;Katz JN;Kent Kwoh C;Kraus VB;Hunter DJ
通讯作者：
Hunter DJ
影响因子：
5
作者：
Bihlet, Asger Reinstrup;Bjerre-Bastos, Jonathan Jetsmark;Bay-Jensen, Anne-Christine
通讯作者：
Bay-Jensen, Anne-Christine
影响因子：
4.6
作者：
Bay-Jensen AC;Bihlet A;Byrjalsen I;Andersen JR;Riis BJ;Christiansen C;Michaelis M;Guehring H;Ladel C;Karsdal MA
通讯作者：
Karsdal MA
影响因子：
5.5
作者：
van de Stadt, Lotte A.;Kroon, Feline P. B.;Thudium, Christian F.;Bay-Jensen, Anne C.;Kloppenburg, Margreet
通讯作者：
Kloppenburg, Margreet