Seroprevalence of IgG Antibodies Directed against Dengue, Chikungunya and West Nile Viruses and Associated Risk Factors in Madagascar, 2011 to 2013.
Seroprevalence of IgG Antibodies Directed against Dengue, Chikungunya and West Nile Viruses and Associated Risk Factors in Madagascar, 2011 to 2013.
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DOI：
10.3390/v15081707
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发表时间：
2023-08-08
期刊：
影响因子：
--
通讯作者：
Andriamandimby SF
中科院分区：
文献类型：
--
作者：
Broban A;Olive MM;Tantely ML;Dorsemans AC;Rakotomanana F;Ravalohery JP;Rogier C;Heraud JM;Andriamandimby SF
虫媒病毒已被证明在马达加斯加传播，包括西尼罗河病毒、登革热病毒和基孔肯雅病毒，尽管它们的传播程度仍然没有得到很好的记录。我们估计了马达加斯加这三种虫媒病毒的血清阳性率，并确定了与血清阳性相关的危险因素。对全国各地哨兵卫生中心网络周围的1680人的血清样本进行了酶联免疫吸附试验和血凝抑制试验，以检测登革热、基孔肯雅和西尼罗河病毒的抗体，并建立了多因素Logistic回归模型。总体而言，登革热病毒血清阳性率为6.5%[IC 95%3.2~9.9]，其中以登革1型为主，基孔肯雅病毒阳性率为13.7%[IC 95%6.5~20.9]，西尼罗河病毒阳性率为12.7%[IC 95%9.0~16.5]。与年龄无关，这表明登革热和基孔肯雅病毒可能是最近引入的。东部和北部地区受登革热和基孔肯雅病毒影响较大，而西尼罗河病毒似乎在全国各地传播。登革热和基孔肯雅热的血清阳性与高植被以及频繁的森林工作有关，与西尼罗河的血清阳性与种植区的存在以及生活水平有关。这一分析使人们对虫媒病毒在马达加斯加的传播和传播模式有了新的认识。
Arboviruses have been shown to circulate in Madagascar, including West Nile, dengue, and chikungunya viruses, though the extent of their circulation remains poorly documented. We estimated the seroprevalence of these three arboviruses in Madagascar and determined risk factors associated with seropositivity. Serum samples obtained from 1680 individuals surrounding the Sentinel Health Centers network in all regions of the country were analyzed using ELISA and hemagglutination inhibition assays for dengue, chikungunya, and West Nile viruses IgG antibodies, and multivariate logistic regression models were run. Overall, 6.5% [IC 95% 3.2–9.9] were seropositive for dengue virus, predominantly of Dengue serotype 1, 13.7% [IC 95% 6.5–20.9] for chikungunya virus, and 12.7% [IC 95% 9.0–16.5] for West Nile virus. There was no association with age, showing that dengue and chikungunya viruses were likely recently introduced. Eastern and Northern parts were more affected by dengue and chikungunya viruses, while West Nile virus seemed to circulate in all parts of the country. Dengue and chikungunya seropositivity were notably associated with high levels of vegetation, as well as frequent work in the forest, and West Nile seropositivity with the presence of cultivated areas, as well as standard of living. This analysis gives a new insight into arboviruses circulation and transmission patterns in Madagascar.
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影响因子：
2.3
作者：
Gray TJ;Webb CE
通讯作者：
Webb CE
影响因子：
3.3
作者：
Sissoko, Daouda;Ezzedine, Khaled;Malvy, Denis
通讯作者：
Malvy, Denis
影响因子：
3.7
作者：
Crepeau TN;Healy SP;Bartlett-Healy K;Unlu I;Farajollahi A;Fonseca DM
通讯作者：
Fonseca DM
影响因子：
11.8
作者：
Schwarz NG;Girmann M;Randriamampionona N;Bialonski A;Maus D;Krefis AC;Njarasoa C;Rajanalison JF;Ramandrisoa HD;Randriarison ML;May J;Schmidt-Chanasit J;Rakotozandrindrainy R
通讯作者：
Rakotozandrindrainy R
影响因子：
4.5
作者：
Randrianasolo, Laurence;Raoelina, Yolande;Richard, Vincent
通讯作者：
Richard, Vincent