Cytokines as the good predictors of refractory Mycoplasma pneumoniae pneumonia in school-aged children.
Cytokines as the good predictors of refractory Mycoplasma pneumoniae pneumonia in school-aged children.
复制标题
细胞因子是学龄儿童难治性肺炎支原体肺炎的良好预测因子。
DOI：
10.1038/srep37037
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发表时间：
2016-11-11
影响因子：
4.6
通讯作者：
Chen Z
中科院分区：
文献类型：
--
作者：
Zhang Y;Mei S;Zhou Y;Huang M;Dong G;Chen Z
对病原体的过度免疫应答可能在难治性肺炎支原体肺炎（RMPP）中起重要作用。本研究的目的是阐明细胞因子与学龄患者RMPP预测之间的关联。对2011年1月1日至2015年12月31日在我院住院的学龄儿童肺炎支原体肺炎（MPP）进行回顾性分析。比较RMPP组与普通型肺炎支原体肺炎（GMPP）组的临床特征，包括血清细胞因子水平，探讨RMPP的预测价值。180例患者中，GMPP组115例，RMPP组65例。RMPP组血清IL-6、IL-10、IFN-γ水平明显高于GMPP组（P < 0.01）。在ROC曲线分析中，IL-10和IFN-γ对RMPP和GMPP的鉴别诊断有一定的意义。Logistic回归分析显示IL-10 ≥ 3.65 pg/ml和IFN-γ ≥ 29.05 pg/ml是RMPP的显著预测因素。此外，观察到血清IL-10和IFN-γ浓度之间呈正相关。结论：IL-10和IFN-γ可作为学龄儿童RMPP的良好预测指标。
Excessive immune response against pathogens may play an important role in refracory Mycoplasma pneumoniae pneumonia (RMPP). The aim of this study was to elucidate the associations between cytokines and the prediction of RMPP in school-aged patients. Retrospective analysis was performed on school-aged children with Mycoplasma pneumoniae pneumonia (MPP) hospitalized in our hospital between January 1, 2011 and December 31, 2015. The clinical charcteristics, including the cytokines in serum between the RMPP group and the general Mycoplasma pneumoniae pneumonia (GMPP) group were compared and the predictive values of RMPP were explored. Of total 180 patients, 115 patients were in the GMPP group, 65 were in the RMPP group. We found the levels of cytokines, including nterleukin (IL)-6, IL-10, interferon gamma (IFN-γ) in RMPP group were significantly higher than those in GMPP group (P < 0.01). In ROC curve analysis, IL-10 and IFN-γ were useful for differentiating patients with RMPP from those with GMPP. Logistic regression analysis showed that the IL-10 ≥ 3.65 pg/ml and IFN-γ ≥ 29.05 pg/ml were significant predictors regarding to RMPP. Additionally, a positive correlation between serum IL-10 and IFN-γ concentrations was observed. Conclusions: IL-10 and IFN-γ could be used as the good predictors of RMPP in school-aged children.
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