Rhinovirus: A Narrative Review on Its Genetic Characteristics, Pediatric Clinical Presentations, and Pathogenesis.
Rhinovirus: A Narrative Review on Its Genetic Characteristics, Pediatric Clinical Presentations, and Pathogenesis.
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DOI：
10.3389/fped.2021.643219
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发表时间：
2021
影响因子：
2.6
通讯作者：
Basmaci R
中科院分区：
文献类型：
--
作者：
Bizot E;Bousquet A;Charpié M;Coquelin F;Lefevre S;Le Lorier J;Patin M;Sée P;Sarfati E;Walle S;Visseaux B;Basmaci R
人类鼻病毒（hrv）是引起普通感冒的主要原因。自2000年代以来，随着新的分子方法的发展，hrv越来越多地参与严重的临床感染。最近对HRV遗传特征的了解也提高了对其发病机制的理解。这篇叙述性综述的目的是提供当前儿科社区关于这种病毒的全面知识。hrv是儿童上呼吸道和下呼吸道感染的主要原因。HRV是儿童细支气管炎和肺炎的第二种病毒，HRV细支气管炎有较高的复发性喘息发作或哮喘风险。最近的一些发现描述了粪便、血液或脑脊液中的hrv，这要归功于新的分子技术，如聚合酶链反应（PCR），通过高灵敏度检测hrv。然而，无症状携带者的高发生率和症状后患者的排泄时间延长使解释变得复杂。没有足够的数据表明在检测到HRV的儿童高危人群中避免抗生素治疗。hrv引起的严重临床表现在具有慢性病理或遗传特殊性的特定人群中更为常见。炎症反应是由核因子(NF)- κ B途径和干扰素(IFN)- β和IFN- γ、白细胞介素8 （IL8）和il - 1b的产生介导的。虽然研究仍在进行中，但目前还没有具体的治疗方法或抗病毒疗法。如今，除了良性疾病外，心率变异也被认为与一些严重的临床表现有关。遗传知识或特异性炎症反应的最新进展可能导致特异性治疗。
Human rhinoviruses (HRVs) are the leading cause of common colds. With the development of new molecular methods since the 2000s, HRVs have been increasingly involved among severe clinical infections. Recent knowledge of the HRV genetic characteristics has also improved the understanding of their pathogenesis. This narrative review aims to provide a current comprehensive knowledge about this virus in the pediatric community. HRVs represent a main cause of upper and lower respiratory tract infections in children. HRV is the second virus involved in bronchiolitis and pneumonia in children, and HRV bronchiolitis has a higher risk of recurrent wheezing episode or asthma. Some recent findings described HRVs in stools, blood, or cerebrospinal fluid, thanks to new molecular techniques such as polymerase chain reaction (PCR) by detecting HRVs with high sensibility. However, the high rate of asymptomatic carriage and the prolonged excretion in postsymptomatic patients complicate interpretation. No sufficient data exist to avoid antibiotic therapy in pediatric high-risk population with HRV detection. Severe clinical presentations due to HRVs can be more frequent in specific population with chronic pathology or genetic particularity. Inflammatory response is mediated by the nuclear factor (NF)-kappa B pathway and production of interferon (IFN)-beta and IFN-gamma, interleukin 8 (IL8), and IL1b. No specific treatment or antiviral therapy exists, although research is still ongoing. Nowadays, in addition to benign diseases, HRVs are recognized to be involved in some severe clinical presentations. Recent advances in genetic knowledge or specific inflammatory response may lead to specific treatment.
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影响因子：
5.4
作者：
Guedán A;Swieboda D;Charles M;Toussaint M;Johnston SL;Asfor A;Panjwani A;Tuthill TJ;Danahay H;Raynham T;Mousnier A;Solari R
通讯作者：
Solari R
DOI：
10.1016/j.jcv.2009.03.008
发表时间：
2009-05
期刊：
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology
影响因子：
--
作者：
Greer RM;McErlean P;Arden KE;Faux CE;Nitsche A;Lambert SB;Nissen MD;Sloots TP;Mackay IM
通讯作者：
Mackay IM
影响因子：
4.9
作者：
Hayden, FG;Turner, RB;Zalman, LS
通讯作者：
Zalman, LS
影响因子：
12.7
作者：
Harvala, H.;McIntyre, C. L.;Simmonds, P.
通讯作者：
Simmonds, P.
DOI：
10.1164/rccm.201701-0120oc
发表时间：
2017-10-15
影响因子：
24.7
作者：
Esquivel, Ann;Busse, William W.;Gern, James E.
通讯作者：
Gern, James E.