G1 Dynamics at the Crossroads of Pluripotency and Cancer.
G1 Dynamics at the Crossroads of Pluripotency and Cancer.
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DOI：
10.3390/cancers15184559
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发表时间：
2023-09-14
期刊：
影响因子：
5.2
通讯作者：
Cook, Jeanette Gowen
中科院分区：
文献类型：
--
作者：
Fleifel, Dalia;Cook, Jeanette Gowen
关键词：
细胞分裂周期受到严格调控，以确保DNA复制的可靠性和完整性。一个关键的细胞周期阶段是G1期，在此期间细胞准备DNA用于S期的复制。有趣的是，干细胞和癌细胞在细胞周期调控机制上既有相似之处，也有不同之处。在这篇综述中，我们解决的作用，各种细胞周期调节剂在控制干细胞和癌细胞的G1期的动态。我们还讨论了在理解核心多能性因子如何调节细胞周期和在干细胞多能性和异常表达的癌症中发挥双重作用方面的最新进展。更好地了解这些常见的调控网络可以为癌症提供潜在的新治疗途径。G1期细胞周期时相动力学是由复杂的网络调控的，包括细胞周期蛋白、细胞周期蛋白依赖性激酶（CDK）和CDK抑制剂，它们控制G1期进展并确保适当的细胞周期转换。G1期是DNA复制的第一步，在随后的S期，适当的起始许可对维持基因组的完整性至关重要。在这篇综述中，我们强调了干细胞和癌细胞之间G1动力学的有趣的相似之处和差异，重点是它们的调节机制和功能结果。值得注意的是，S 0X 2、0 CT 4、KLF 4和多能性重编程促进剂c-MYC（其在建立和维持干细胞多能性中的作用是已知的）也在某些癌细胞中异常表达。在这篇综述中，我们讨论了最近的进展，了解这些多能性因子在G1动力学的背景下，干细胞和癌细胞，这可能会提供新的见解多能性和肿瘤发生之间的相互联系。
The cell division cycle is tightly regulated to ensure faithful and complete DNA replication. A critical cell cycle phase is G1 in which cells prepare DNA for replication in S phase. Interestingly, stem cells and cancer cells have both similarities and differences in their cell cycle regulatory mechanisms. In this review, we address the role of various cell cycle regulators in controlling the dynamics of G1 phase in stem cells and cancer cells. We also discuss recent advances in understanding how core pluripotency factors regulate the cell cycle and play dual roles in stem cell pluripotency and in cancers where they are aberrantly expressed. A better understanding of these common regulatory networks could offer potential new therapeutic avenues for cancer. G1 cell cycle phase dynamics are regulated by intricate networks involving cyclins, cyclin-dependent kinases (CDKs), and CDK inhibitors, which control G1 progression and ensure proper cell cycle transitions. Moreover, adequate origin licensing in G1 phase, the first committed step of DNA replication in the subsequent S phase, is essential to maintain genome integrity. In this review, we highlight the intriguing parallels and disparities in G1 dynamics between stem cells and cancer cells, focusing on their regulatory mechanisms and functional outcomes. Notably, SOX2, OCT4, KLF4, and the pluripotency reprogramming facilitator c-MYC, known for their role in establishing and maintaining stem cell pluripotency, are also aberrantly expressed in certain cancer cells. In this review, we discuss recent advances in understanding the regulatory role of these pluripotency factors in G1 dynamics in the context of stem cells and cancer cells, which may offer new insights into the interconnections between pluripotency and tumorigenesis.
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