Toll-like receptors as targets in chronic liver diseases.
Toll-like receptors as targets in chronic liver diseases.
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DOI：
10.1136/gut.2008.156307
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发表时间：
2009-05
期刊：
影响因子：
24.5
通讯作者：
Schwabe RF
中科院分区：
文献类型：
--
作者：
Mencin A;Kluwe J;Schwabe RF
Toll样受体（TLR）识别病原体相关分子模式（PAMP）以检测病原体的存在。除了它们在先天免疫中的作用之外，TLR还在炎症的调节中发挥重要作用，即使在无菌条件下，例如损伤和伤口愈合。这种参与已被认为至少部分取决于TLR识别几种称为损伤相关分子模式（DAMP）的内源性TLR配体的能力。肝脏不仅在许多疾病状态中代表细菌PAMP的主要靶点，而且在损伤后上调几种DAMP。因此，TLR介导的信号已经涉及许多慢性肝病。在这里，我们将总结TLR和TLR配体在肝纤维化和肝硬化，病毒性肝炎，酒精性肝病，非酒精性脂肪性肝病和肝细胞癌的病理生理学中的作用的最新研究结果，并强调TLR激动剂，拮抗剂和益生菌治疗慢性肝病的潜在作用。
Toll-like receptors (TLRs) recognize pathogen associated molecular patterns (PAMPs) to detect the presence of pathogens. In addition to their role in innate immunity, TLRs also play a major role in the regulation of inflammation, even under sterile conditions such as injury and wound healing. This involvement has been suggested to be depend, at least in part, on the ability of TLRs to recognize several endogenous TLR ligands termed damage associated molecular patterns (DAMPs). The liver not only represents a major target of bacterial PAMPs in many disease states but also upregulates several DAMPs following injury. Accordingly, TLR-mediated signals have been implicated in a number of chronic liver diseases. Here, we will summarize recent findings on the role TLRs and TLR ligands in the pathophysiology of liver fibrosis and cirrhosis, viral hepatitis, alcoholic liver disease, non-alcoholic fatty liver disease and hepatocellular carcinoma, and highlight the potential role of TLR agonists, antagonists and probiotics for the treatment of chronic liver disease.
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DOI：
10.1084/jem.110.1.27
发表时间：
1959-07-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
BENACERRAF B;SEBESTYEN MM;SCHLOSSMAN S
通讯作者：
SCHLOSSMAN S
影响因子：
7.7
作者：
Cani, Patrice D.;Amar, Jacques;Burcelin, Remy
通讯作者：
Burcelin, Remy
影响因子：
13.5
作者：
Adawi, D;Kasravi, FB;Jeppsson, B
通讯作者：
Jeppsson, B
抑制白介素1受体/TOLL样受体信号传导通过剪接的短形式的MyD88抑制是由于其未能募集IRAK-4所致。
影响因子：
15.3
作者：
Burns, K;Janssens, S;Brissoni, B;Olivos, N;Beyaert, R;Tschopp, J
通讯作者：
Tschopp, J
影响因子：
9.8
作者：
Bajaj, Jasmohan S.;Saeian, Kia;Binion, David G.
通讯作者：
Binion, David G.