Luteotropic Mechanisms in the Bovine Corpus Luteum: Role of Oxytocin, Prostaglandin F2 α, Progesterone and Noradrenaline

Luteotropic Mechanisms in the Bovine Corpus Luteum: Role of Oxytocin, Prostaglandin F2 α, Progesterone and Noradrenaline
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牛黄体的促黄体机制:催产素、前列腺素 F2 α、黄体酮和去甲肾上腺素的作用

DOI:
10.1262/jrd.47.125
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发表时间:
2001
影响因子:
1.8
通讯作者:
K. Okuda
K. Okuda
中科院分区:
生物学3区
文献类型:
--
作者:
D. Skarżyński;J. Jaroszewski;K. Okuda

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黄体(CL)的主要功能是产生孕酮(P4)。有足够的黄体功能来分泌P4对于决定发情周期的生理持续时间和获得成功妊娠至关重要。牛CL生长很快,黄体溶解后两天内退化。控制牛CL发育和分泌功能的机制可能涉及CL内外产生的许多因素。其中一些调节剂似乎是前列腺素(PGs)、催产素(OT)和去甲肾上腺素(NA)等肾上腺素能因子。最近,有一些证据表明,P4在牛CL内作为自分泌和/或旁分泌调节。这些因素中的每一个都可以独立地作用于CL,也可以改变其他因素的作用。本文的目的是综述和讨论OT、PGs、P4和NA在牛CL中作为促黄体自身/旁分泌调节因子的可能作用。此外,还讨论了黄体内控制CL对性腺外PGF_2α敏感性的机制。
The main function of the corpus luteum (CL) is production of progesterone (P4). Adequate luteal function to secrete P4 is crucial for determining the physiological duration of the estrous cycle and for achieving a successful pregnancy. The bovine CL grows very fast and regresses within two days at luteolysis. The mechanism controlling the development and secretory function of the bovine CL may involve many factors that are produced both within and outside the CL. Some of these regulators seem to be prostaglandins (PGs), oxytocin (OT) and adrenergic factors such as noradrenaline (NA). Recently, there has been some evidence that P4 acts within the bovine CL as an autocrine and/or paracrine regulator. Each of these factors may act on the CL independently or may modify the actions of others. The purpose of this paper is to review and discuss the possible roles of OT, PGs, P4 and NA as luteotropic auto/paracrine regulators in the bovine CL. Furthermore, intra-luteal mechanisms controlling the sensitivity of the CL to extragonadal PGF2α are discussed.
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