Design and optimization of coin-shaped microreactor chips for PET radiopharmaceutical synthesis.
Design and optimization of coin-shaped microreactor chips for PET radiopharmaceutical synthesis.
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DOI：
10.2967/jnumed.109.065946
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发表时间：
2010-02
期刊：
影响因子：
--
通讯作者：
Heath JR
中科院分区：
文献类型：
--
作者：
Elizarov AM;van Dam RM;Shin YS;Kolb HC;Padgett HC;Stout D;Shu J;Huang J;Daridon A;Heath JR
一种集成的弹性体微流体装置，其占地面积与邮票大小相同，专为 PET 示踪剂的多步放射合成而设计和优化。该设备的独特架构以 5 μL 硬币形反应器为中心，通过高试剂浓度、加压反应以及快速传热传质的组合来提高反应效率和速度。其新颖的功能有利于混合、溶剂交换和产品收集。利用真空、压力和化学反应辅助的新混合机制。所报道的反应器的架构是第一个允许批量模式微流体装置生产质量和数量足以通过体内成像验证的放射性药物的架构。该反应堆有潜力生产多种人体剂量的 18F-FDG；然而，预计影响最大的是 PET 放射性药物的合成，目前可用的设备只能以较低的产量进行合成。
An integrated elastomeric microfluidic device, with a footprint the size of a postage stamp, has been designed and optimized for multistep radiosynthesis of PET tracers. The unique architecture of the device is centered around a 5-μL coin-shaped reactor, which yields reaction efficiency and speed from a combination of high reagent concentration, pressurized reactions, and rapid heat and mass transfer. Its novel features facilitate mixing, solvent exchange, and product collection. New mixing mechanisms assisted by vacuum, pressure, and chemical reactions are exploited. The architecture of the reported reactor is the first that has allowed batch-mode microfluidic devices to produce radiopharmaceuticals of sufficient quality and quantity to be validated by in vivo imaging. The reactor has the potential to produce multiple human doses of 18F-FDG; the most impact, however, is expected in the synthesis of PET radiopharmaceuticals that can be made only with low yields by currently available equipment.
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