Photosensitizer-loaded biomimetic platform for multimodal imaging-guided synergistic phototherapy.
Photosensitizer-loaded biomimetic platform for multimodal imaging-guided synergistic phototherapy.
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用于多模态成像引导协同光疗的光敏剂仿生平台
DOI：
10.1039/c8ra04663h
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发表时间：
2018-09-12
期刊：
影响因子：
3.9
通讯作者：
Lu, Guangming
中科院分区：
文献类型：
--
作者：
Tian, Ying;Zhao, Ying;Liu, Wenfei;Liu, Ying;Tang, Yuxia;Teng, Zhaogang;Zhang, Chunni;Wang, Shouju;Lu, Guangming
光动力学疗法（PDT）作为肿瘤治疗的一种策略已引起广泛关注。然而，大多数光敏剂的不溶性和肿瘤靶向性差阻碍了PDT的进一步发展。因此，有必要探索具有良好水溶性和生物相容性的新型载体，将PS递送到肿瘤中。黑色素纳米颗粒是一种新型的仿生纳米载体，具有良好的生物相容性、负载能力、光热治疗（PTT）和磁共振（MR）/光声（PA）成像性能。本文设计了聚多巴胺黑色素纳米颗粒（PDMNs）作为光敏剂二氢卟酚e6（PDMN-Ce 6）的载体，并实现了其作为肿瘤治疗诊断剂的应用。PDMN-Ce 6具有优异的生物相容性、良好的水溶性和Ce 6的高负载能力（35.2wt%）。与游离Ce 6相比，PDMN-Ce 6在体外研究中显示出更高的细胞内化和上级协同光疗效果。一项体内研究表明，PDMN-Ce 6在肿瘤部位的积累是注射后24小时游离Ce 6的2.8倍，这有利于MR/PA成像。此外，协同治疗显著抑制肿瘤生长，导致肿瘤坏死和肿瘤血管生成抑制。这些结果表明，我们的仿生和生物相容性平台可以提高Ce 6到肿瘤的递送，并实现多模式成像引导的肿瘤协同光疗。
Photodynamic therapy (PDT) has attracted much attention as a strategy for tumor therapy. However, the insolubility and poor tumor-targeting ability of most photosensitizers (PSs) hinder PDT from further development. Therefore, it is necessary to explore new carriers with good water solubility and biocompatibility to deliver PSs to tumors. Melanin nanoparticles are novel biomimetic nanocarriers with excellent biocompatibility, loading capacity, photothermal therapy (PTT) and magnetic resonance (MR)/photoacoustic (PA) imaging properties. Here we designed polydopamine melanin nanoparticles (PDMNs) as a delivery platform for the photosensitizer Chlorin e6 (PDMN–Ce6) and realized its application as a theranostic agent for tumor therapy. The PDMN–Ce6 exhibited excellent biocompatibility, good water solubility and high loading capability (35.2 wt%) for Ce6. Compared with the free Ce6, PDMN–Ce6 showed higher cellular internalization and superior synergistic phototherapy effects in an in vitro study. An in vivo study indicated that the accumulation of PDMN–Ce6 at tumor sites was 2.8-fold higher than that of free Ce6 at 24 h post-injection, which was beneficial for MR/PA imaging. Moreover, the synergetic therapy significantly inhibited tumor growth, causing tumor necrosis and tumor angiogenesis suppression. These results suggest that our biomimetic and biocompatible platform could improve the delivery of Ce6 to tumors and realize multimodal imaging-guided tumor synergetic phototherapy.
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影响因子：
46.2
作者：
Sharifi S;Behzadi S;Laurent S;Forrest ML;Stroeve P;Mahmoudi M
通讯作者：
Mahmoudi M
TAT肽官能化的金纳米级：使用超低辐照度增强了细胞内递送和有效的NIR光热治疗。
影响因子：
15
作者：
Yuan, Hsiangkuo;Fales, Andrew M.;Vo-Dinh, Tuan
通讯作者：
Vo-Dinh, Tuan
通过具有紫外线和伽马射线防护的多功能仿生治疗学进行多模态成像引导的癌症光疗
DOI：
10.1002/adma.201505700
发表时间：
2016-05
期刊：
Advanced materials (Deerfield Beach, Fla.)
影响因子：
--
作者：
Lin J;Wang M;Hu H;Yang X;Wen B;Wang Z;Jacobson O;Song J;Zhang G;Niu G;Huang P;Chen X
通讯作者：
Chen X
金纳米团簇和光敏剂双负载时空可控脂质体纳米复合材料通过抑制硫氧还蛋白还原酶增强肿瘤光动力治疗效果
影响因子：
10
作者：
Gao, Fuping;Zheng, Weiping;Gao, Xueyun
通讯作者：
Gao, Xueyun
影响因子：
10
作者：
Longo, Dario L.;Stefania, Rachele;Aime, Silvio
通讯作者：
Aime, Silvio