Pharmacokinetic and chemoprevention studies on tea in humans.
Pharmacokinetic and chemoprevention studies on tea in humans.
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关于人类茶的药代动力学和化学预防研究。
DOI：
10.1016/j.phrs.2011.05.007
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发表时间：
2011-08
影响因子：
9.3
通讯作者：
Hakim, Iman A.
中科院分区：
文献类型：
--
作者：
Chow, H. -H. Sherry;Hakim, Iman A.
绿色茶及其主要的多酚成分，儿茶素，已被证明具有许多健康益处，包括预防癌症。口服绿色茶或绿色茶儿茶素后，茶儿茶素和茶儿茶素代谢物/儿茶素在体循环中是生物可利用的。在人体中发现的代谢物/催化剂包括葡糖苷酸/硫酸盐结合物、甲基化茶儿茶素结合物、微生物群介导的环分裂产物和酚酸催化剂。人体中未改变的茶儿茶素的血浆水平大多在亚μM或nM浓度范围内，这远低于大多数体外研究中确定的有效浓度。然而，一些儿茶素代谢物/儿茶素在体循环中的水平远高于母体儿茶素的水平。儿茶素衍生的代谢物/儿茶素对与绿色茶相关的生物效应的贡献尚未确定。迄今为止，已经进行了有限数量的绿色茶或绿色茶儿茶素的化学预防试验，并且已经观察到对口腔癌、前列腺癌和结肠直肠癌的潜在预防活性。来自多个正在进行的干预试验的新数据将进一步有助于定义绿色茶或绿色茶儿茶素的癌症预防活性。
Green tea and its major polyphenols constituents, tea catechins, have been shown to have many health benefits including cancer prevention. Tea catechins and tea catechin metabolites/catabolites are bioavailable in the systemic circulation after oral intake of green tea or green tea catechins. The metabolites/catabolites identified in humans include glucuronide/sulfate conjugates, methylated tea catechin conjugates, and microflora-mediated ring fission products and phenolic acid catabolites. Plasma levels of unchanged tea catechins in humans are mostly in the sub-μM or nM concentration range, which is much lower than the effective concentrations determined in most in vitro studies. However, some of the catechin metabolites/catabolites are present in the systemic circulation at levels much higher than those of the parent catechins. The contribution of catechin derived metabolites/catabolites to the biological effects associated with green tea is yet to be defined. A limited number of chemoprevention trials of green tea or green tea catechins have been conducted to date and have observed potential preventive activity for oral, prostate, and colorectal cancer. Emerging data from multiple ongoing intervention trials will further contribute to defining the cancer preventive activity of green tea or green tea catechins.
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影响因子：
3.8
作者：
Hakim, IA;Harris, RB;Ali, IU
通讯作者：
Ali, IU
影响因子：
3.9
作者：
Cai, Y;Anavy, ND;Chow, HHS
通讯作者：
Chow, HHS
影响因子：
4.2
作者：
Hakim, IA;Harris, RB;Talbot, W
通讯作者：
Talbot, W
影响因子：
4.2
作者：
Henning, Susanne M.;Aronson, William;Heber, David
通讯作者：
Heber, David
DOI：
10.1046/j.1525-1373.1999.d01-37.x
发表时间：
1999-04-01
影响因子：
--
作者：
Li, N;Sun, Z;Chen, JS
通讯作者：
Chen, JS