Central expression and anorectic effect of brain-derived neurotrophic factor are regulated by circulating estradiol levels.
Central expression and anorectic effect of brain-derived neurotrophic factor are regulated by circulating estradiol levels.
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DOI：
10.1016/j.yhbeh.2013.01.009
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发表时间：
2013-03
影响因子：
3.5
通讯作者：
Shi, Haifei
中科院分区：
文献类型：
--
作者：
Zhu, Zheng;Liu, Xian;Kumar, Shiva Priya Dharshan Senthil;Zhang, Jing;Shi, Haifei
雌激素能有效地抑制食物的摄入。令人信服的证据表明，雌二醇，雌激素的主要形式，通过促进其他厌食信号减少食物摄入。脑源性神经营养因子（BDNF），像雌二醇一样，似乎通过影响膳食量来抑制食物摄入。我们假设雌二醇调节BDNF的表达和BDNF的厌食作用。第一个目标是确定是否BDNF的表达调节内源性雌二醇的循环大鼠和周期性雌二醇治疗卵巢切除大鼠。BDNF的表达在下丘脑腹内侧核（VMH）暂时升高，在发情期后的雌二醇峰值，这正好与在卵巢周期的这个阶段的喂养下降。此外，卵巢切除后食物摄入量和体重增加，同时VMH中BDNF表达减少。所有这些变化都被逆转的周期性雌二醇治疗，表明在VMH内的BDNF表达的调节雌二醇依赖的方式。第二个目标是确定雌二醇是否调节BDNF的厌食作用。假手术动情期大鼠和周期性雌二醇治疗的卵巢切除大鼠对较低剂量的BDNF中枢给药的反应比雄性大鼠和油治疗的卵巢切除大鼠减少摄食量，这意味着内源性雌二醇或周期性雌二醇替代增加了对BDNF厌食作用的敏感性。这些数据表明，BDNF的VMH内的表达和BDNF的厌食作用取决于血浆雌二醇水平，表明雌二醇可能通过调节BDNF信号来调节摄食。
Estrogens potently suppress food intake. Compelling evidence suggests that estradiol, the primary form of estrogens, reduces food intake by facilitating other anorectic signals. Brain-derived neurotrophic factor (BDNF), like estradiol, appears to suppress food intake by affecting meal size. We hypothesized that estradiol modulates Bdnf expression and the anorectic effect of BDNF. The first goal was to determine whether Bdnf expression was regulated by endogenous estradiol of cycling rats and by cyclic estradiol treatment using ovariectomized rats. Bdnf expression within the ventromedial nucleus of hypothalamus (VMH) was temporally elevated at estrus following the estradiol peak, which coincided with the decline in feeding at this phase of the ovarian cycle. Additionally, food intake and body weight were increased following ovariectomy with a parallel decrease in Bdnf expression in the VMH. All of these alterations were reversed by cyclic estradiol treatment, suggesting that Bdnf expression within the VMH was regulated in an estradiol-dependent manner. The second goal was to determine whether estradiol modulates the anorectic effect of BDNF. Sham-operated estrous rats and ovariectomized rats cyclically treated with estradiol responded to a lower dose of central administration of BDNF to decrease food intake than male rats and oil-treated ovariectomized rats, implying that endogenous estradiol or cyclic estradiol replacement increased the sensitivity to anorectic effect of BDNF. These data indicate that Bdnf expression within the VMH and the anorectic effect of BDNF varied depending on plasma estradiol levels, suggesting that estradiol may regulate BDNF signaling to regulate feeding.
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影响因子：
3
作者：
Eckel, LA;Geary, N
通讯作者：
Geary, N
影响因子：
3.5
作者：
Asarian, L;Geary, N
通讯作者：
Geary, N
影响因子：
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作者：
GEARY, N;TRACE, D;SMITH, GP
通讯作者：
SMITH, GP
影响因子：
3.3
作者：
Komori, T.;Morikawa, Y.;Senba, E.
通讯作者：
Senba, E.
影响因子：
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作者：
Geary, N;Asarian, L;Ogawa, S
通讯作者：
Ogawa, S