Bioactive Lipids and Chronic Inflammation: Managing the Fire Within.
Bioactive Lipids and Chronic Inflammation: Managing the Fire Within.
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DOI：
10.3389/fimmu.2018.00038
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发表时间：
2018
影响因子：
7.3
通讯作者：
Maccarrone M
中科院分区：
文献类型：
--
作者：
Chiurchiù V;Leuti A;Maccarrone M
炎症是一种免疫反应，其作为一种包含的火起作用，其在感染期间或在任何类型的组织损伤时作为防御过程被先发制人地点燃，并且在消除或终止损伤后自发地熄灭。然而，持续和不受控制的免疫反应就像野火一样，促进慢性炎症，未解决的组织损伤，最终导致慢性疾病。一个广泛的可溶性介质网络，其中包括内源性生物活性脂质，控制着所有的免疫过程。它们基本上由参与炎症过程的所有细胞分泌，并构成触发、协调和限制炎症机制的关键基础设施。然而，这些分子也深深地参与了从急性炎症到慢性炎症的有害转变，无论是促炎脂质的持续或过度作用，还是对由消退脂质进行的功能的损害。事实上，迄今为止，生物活性脂质已经与几种慢性疾病有关，包括类风湿性关节炎、动脉粥样硬化、糖尿病、癌症、炎症性肠病、系统性红斑狼疮和多发性硬化症。本文综述了目前的知识参与的主要类别的内源性生物活性脂质，即经典的类花生酸，亲解决脂质介质，lysoglycerophospholipids/鞘脂，endocannabinoids的细胞和分子机制，导致慢性疾病的发病机制。
Inflammation is an immune response that works as a contained fire that is pre-emptively sparked as a defensive process during infections or upon any kind of tissue insult, and that is spontaneously extinguished after elimination or termination of the damage. However, persistent and uncontrolled immune reactions act as a wildfire that promote chronic inflammation, unresolved tissue damage and, eventually, chronic diseases. A wide network of soluble mediators, among which endogenous bioactive lipids, governs all immune processes. They are secreted by basically all cells involved in inflammatory processes and constitute the crucial infrastructure that triggers, coordinates and confines inflammatory mechanisms. However, these molecules are also deeply involved in the detrimental transition from acute to chronic inflammation, be it for persistent or excessive action of pro-inflammatory lipids or for the impairment of the functions carried out by resolving ones. As a matter of fact, bioactive lipids have been linked, to date, to several chronic diseases, including rheumatoid arthritis, atherosclerosis, diabetes, cancer, inflammatory bowel disease, systemic lupus erythematosus, and multiple sclerosis. This review summarizes current knowledge on the involvement of the main classes of endogenous bioactive lipids—namely classical eicosanoids, pro-resolving lipid mediators, lysoglycerophospholipids/sphingolipids, and endocannabinoids—in the cellular and molecular mechanisms that lead to the pathogenesis of chronic disorders.
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影响因子：
4
作者：
Chiurchiu, Valerio;Maccarrone, Mauro
通讯作者：
Maccarrone, Mauro
影响因子：
11.2
作者：
Chiurchiu, Valerio;Cencioni, Maria Teresa;Maccarrone, Mauro
通讯作者：
Maccarrone, Mauro
专门的促解决介质：感染和炎症的内源性调节剂。
DOI：
10.1038/nri.2015.4
发表时间：
2016-01
期刊：
Nature reviews. Immunology
影响因子：
--
作者：
Basil MC;Levy BD
通讯作者：
Levy BD
影响因子：
32.4
作者：
Buckley, Christopher D.;Gilroy, Derek W.;Serhan, Charles N.
通讯作者：
Serhan, Charles N.
DOI：
10.1016/j.plefa.2005.05.003
发表时间：
2005-09-01
影响因子：
3
作者：
Chiang, N;Arita, M;Serhan, CN
通讯作者：
Serhan, CN