Recombinant human GLP-1 beinaglutide regulates lipid metabolism of adipose tissues in diet-induced obese mice.
Recombinant human GLP-1 beinaglutide regulates lipid metabolism of adipose tissues in diet-induced obese mice.
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DOI：
10.1016/j.isci.2021.103382
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发表时间：
2021-12-17
期刊：
影响因子：
5.8
通讯作者：
Hu F
中科院分区：
文献类型：
--
作者：
Zhang F;Chen Z;Wu D;Tian L;Chen Q;Ye Y;Chen W;Wu X;Wu P;Yuan W;Qiu Y;Zhou Z;Du Z;Hu F
GLP-1类似物是一类对糖尿病有多种益处的降糖剂，但其在脂肪组织中的作用尚不清楚。本研究旨在探讨重组人GLP-1(rhGLP-1)对脂肪组织胰岛素敏感性和脂代谢的影响。我们已经证明，注射BN后，肥胖小鼠的体重、脂肪质量和血脂水平都较低。此外，BN还可促进白色脂肪组织的胰岛素敏感性。此外，我们还发现，BN处理引起了不同脂类的含量和组成的显著变化，包括甘油脂、甘油磷脂和鞘磷脂，以及脂肪组织中脂代谢途径中的基因表达。综上所述，我们的研究结果表明，BN可以通过靶向脂肪组织中主要脂类的组成和脂肪组织脂代谢相关基因的表达来对抗HFD诱导的肥胖。重组人GLP-1 Beinagluide(BN)降低高脂饮食诱导的肥胖BN在体内增加脂肪细胞的胰岛素敏感性，在体外BN改变肥胖小鼠脂肪组织的脂体学和转录组分谱BN促进脂肪组织中致热基因的表达分子生理学；细胞生物学；脂质组学
GLP-1 analogs are a class of glucose-lowering agents with multiple benefits in diabetes, but its role in adipose tissues remains to be elucidated. The aim of this study was to determine the action of recombinant human GLP-1 (rhGLP-1) Beinaglutide (BN) in the insulin sensitivity and lipid metabolism of adipose tissues. We have shown that, after BN injection, obese mice displayed lower body weight, fat mass, and plasma lipid levels. In addition, BN promoted the insulin sensitivity in the white adipose tissues. Furthermore, we have found that the BN treatment caused significant changes in content and composition of different lipid classes, including glycerolipids, glycerophospholipids, and sphingolipids, as well as expression of genes in lipid metabolic pathways in the adipose tissues. Taken together, our data demonstrate that BN could resist HFD-induced obesity by targeting the composition of major lipid classes and the expression of genes in lipid metabolism of adipose tissues. Recombinant human GLP-1 Beinaglutide (BN) reduces high-fat-diet-induced obesity BN increases insulin sensitivity of adipocytes in vivo and in vitro BN alters lipidomic and transcriptomic profiles in adipose tissues of obese mice BN promotes thermogenic gene expression in adipose tissues Molecular physiology; Cell biology; Lipidomics
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影响因子：
3.7
作者：
Caesar R;Manieri M;Kelder T;Boekschoten M;Evelo C;Müller M;Kooistra T;Cinti S;Kleemann R;Drevon CA
通讯作者：
Drevon CA
影响因子：
8.1
作者：
Grzybek, Michal;Palladini, Alessandra;Coskun, Uenal
通讯作者：
Coskun, Uenal
影响因子：
6.1
作者：
Fang, Xiankang;Du, Zhiqiang;Zuo, Yajun
通讯作者：
Zuo, Yajun
影响因子：
4
作者：
Buganova, Martina;Pelantova, Helena;Haluzik, Martin
通讯作者：
Haluzik, Martin
影响因子：
8.8
作者：
Erion KA;Corkey BE
通讯作者：
Corkey BE