CNS-resident glial progenitor/stem cells produce Schwann cells as well as oligodendrocytes during repair of CNS demyelination.
CNS-resident glial progenitor/stem cells produce Schwann cells as well as oligodendrocytes during repair of CNS demyelination.
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DOI：
10.1016/j.stem.2010.04.002
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发表时间：
2010-06-04
期刊：
影响因子：
23.9
通讯作者：
Franklin RJ
中科院分区：
文献类型：
--
作者：
Zawadzka M;Rivers LE;Fancy SP;Zhao C;Tripathi R;Jamen F;Young K;Goncharevich A;Pohl H;Rizzi M;Rowitch DH;Kessaris N;Suter U;Richardson WD;Franklin RJ
在中枢神经系统（CNS）脱髓鞘后-例如在多发性硬化期间发生的-通常存在髓鞘的自发再生，主要由少突胶质细胞，但也由许旺细胞。髓鞘再生细胞的起源以前尚未确定。我们已经使用Cre-lox基因在转基因小鼠的命运映射，以显示PDGFRA/NG 2表达的神经胶质细胞，在成人中枢神经系统中的干/祖细胞的分布人口，产生髓鞘再生少突胶质细胞和几乎所有的化学诱导脱髓鞘病变的雪旺细胞。相反，病变附近的绝大多数反应性星形胶质细胞来源于预先存在的FGFR 3表达细胞，可能是星形胶质细胞。这些数据解决了关于CNS髓鞘再生主要参与者的起源的长期争论，并揭示了CNS前体产生雪旺细胞的惊人能力，雪旺细胞通常从胚胎神经嵴发育，仅限于外周神经系统。
After central nervous system (CNS) demyelination—such as occurs during multiple sclerosis—there is often spontaneous regeneration of myelin sheaths, mainly by oligodendrocytes but also by Schwann cells. The origins of the remyelinating cells have not previously been established. We have used Cre-lox fate mapping in transgenic mice to show that PDGFRA/NG2-expressing glia, a distributed population of stem/progenitor cells in the adult CNS, produce the remyelinating oligodendrocytes and almost all of the Schwann cells in chemically induced demyelinated lesions. In contrast, the great majority of reactive astrocytes in the vicinity of the lesions are derived from preexisting FGFR3-expressing cells, likely to be astrocytes. These data resolve a long-running debate about the origins of the main players in CNS remyelination and reveal a surprising capacity of CNS precursors to generate Schwann cells, which normally develop from the embryonic neural crest and are restricted to the peripheral nervous system.
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