Integration of O-GlcNAc into Stress Response Pathways.
Integration of O-GlcNAc into Stress Response Pathways.
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作者：
O-连接的β-N-乙酰葡萄糖胺（O-GlcNAc）对核蛋白、线粒体蛋白和胞浆蛋白的修饰已成为哺乳动物蛋白质的动态和必需的翻译后修饰。O-GlcNAc响应于影响蛋白质功能的不同刺激而在5000多种蛋白质上循环打开和关闭，并且进而影响表观遗传学和转录、翻译和蛋白质稳态、代谢、细胞结构和信号转导。环境和生理损伤导致O-GlcNAc化的复杂变化，其影响热休克、渗透应激、氧化应激和缺氧/复氧损伤以及缺血再灌注损伤模型中的细胞和组织存活。似乎支持O-GlcNAc介导的存活的许多机制包括分子伴侣水平的变化、对未折叠蛋白反应和整合应激反应的影响、线粒体功能的改善和蛋白质聚集的减少。在这里，我们讨论了O-GlcNAc整合到细胞应激反应中的点，重点是它在心血管系统和神经退行性变中的作用。
The modification of nuclear, mitochondrial, and cytosolic proteins by O-linked βN-acetylglucosamine (O-GlcNAc) has emerged as a dynamic and essential post-translational modification of mammalian proteins. O-GlcNAc is cycled on and off over 5000 proteins in response to diverse stimuli impacting protein function and, in turn, epigenetics and transcription, translation and proteostasis, metabolism, cell structure, and signal transduction. Environmental and physiological injury lead to complex changes in O-GlcNAcylation that impact cell and tissue survival in models of heat shock, osmotic stress, oxidative stress, and hypoxia/reoxygenation injury, as well as ischemic reperfusion injury. Numerous mechanisms that appear to underpin O-GlcNAc-mediated survival include changes in chaperone levels, impacts on the unfolded protein response and integrated stress response, improvements in mitochondrial function, and reduced protein aggregation. Here, we discuss the points at which O-GlcNAc is integrated into the cellular stress response, focusing on the roles it plays in the cardiovascular system and in neurodegeneration.
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DOI：
10.15252/embj.2021108443
发表时间：
2022-04-19
期刊：
The EMBO journal
影响因子：
--
作者：
通讯作者：
--
DOI：
10.1042/bcj20200609
发表时间：
2021-07-30
期刊：
The Biochemical journal
影响因子：
--
作者：
Balana AT;Pratt MR
通讯作者：
Pratt MR
影响因子：
--
作者：
Cunha-Oliveira T;Montezinho L;Mendes C;Firuzi O;Saso L;Oliveira PJ;Silva FSG
通讯作者：
Silva FSG
α-突触核蛋白淀粉样蛋白劫持了prion蛋白以获得细胞的进入，促进细胞到细胞扩散并阻止prion复制。
影响因子：
4.6
作者：
Aulić S;Masperone L;Narkiewicz J;Isopi E;Bistaffa E;Ambrosetti E;Pastore B;De Cecco E;Scaini D;Zago P;Moda F;Tagliavini F;Legname G
通讯作者：
Legname G
影响因子：
8.8
作者：
Alejandro EU;Bozadjieva N;Kumusoglu D;Abdulhamid S;Levine H;Haataja L;Vadrevu S;Satin LS;Arvan P;Bernal-Mizrachi E
通讯作者：
Bernal-Mizrachi E