Community-directed vector control to supplement mass drug distribution for onchocerciasis elimination in the Madi mid-North focus of Northern Uganda.
Community-directed vector control to supplement mass drug distribution for onchocerciasis elimination in the Madi mid-North focus of Northern Uganda.
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DOI：
10.1371/journal.pntd.0006702
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发表时间：
2018-08
影响因子：
3.8
通讯作者：
Unnasch TR
中科院分区：
文献类型：
--
作者：
Jacob BG;Loum D;Lakwo TL;Katholi CR;Habomugisha P;Byamukama E;Tukahebwa E;Cupp EW;Unnasch TR
盘尾丝虫病是一种被忽视的热带疾病，在历史上一直是发展中国家发病的主要原因和经济发展的障碍。它是由旋毛虫感染引起的，旋毛虫是由蚋属的黑蝇传播的。伊维菌素（Mectizan）对O.微丝蚴扭转及其制造商决定捐赠治疗盘尾丝虫病的药物，促使执行了控制和最近消除这一祸害的国际方案。这些方案主要依靠向受影响的人群大量分发伊维菌素（MDA）。然而，在传播强烈和伊维菌素MDA因与Loa loa的共同地方性而被排除的情况下，单独使用MDA不足以消除盘尾丝虫病。在这些情况下，可能需要将病媒控制作为补充干预措施。由于叮咬的黑蝇载体往往是一个主要的滋扰盘尾丝虫病患病的社区，我们假设，社区成员可能会被动员起来，以清除繁殖地的植被，代表主要的黑蝇幼虫附着点。我们评估了在乌干达北方多个社区进行这种基于社区的“削减和清除”干预的效果。Slash和Clear导致病媒叮咬率下降89-99%。干预后的效果持续了120天。Slash和clear可能是一种有效、廉价、以社区为基础的工具，可以补充伊维菌素的分发，作为消除盘尾丝虫病和预防复发的一种辅助方法。河盲症是发展中国家最重要的发病原因之一。伊维菌素的发现及其制造商决定捐赠用于治疗河盲症的药物，催生了通过大规模治疗患病人群来消除河盲症的计划的发展。但是，单靠伊维菌素并不能在非洲大部分地区消除河盲症，还需要采取额外的干预措施。我们表明，一个简单的社区为基础的方法来控制黑蝇媒介的结果在媒介人口的显着减少。这种以社区为基础的病媒控制方法将与社区驱动的大规模药物管理方案相兼容，这些方案分发伊维菌素以消除非洲的盘尾丝虫病。这应有助于减少实现消除所需的时间，并有助于防止消除后复发。
Onchocerciasis a neglected tropical disease that historically has been a major cause of morbidity and an obstacle to economic development in the developing world. It is caused by infection with Onchocerca volvulus, which is transmitted by black flies of the genus Simulium. The discovery of the potent effect of Mectizan (ivermectin) on O. volvulus microfilariae and the decision by its manufacturer to donate the drug for onchocerciasis spurred the implementation of international programs to control and, more recently, eliminate this scourge. These programs rely primarily on mass distribution of ivermectin (MDA) to the afflicted populations. However, MDA alone will not be sufficient to eliminate onchocerciasis where transmission is intense and where ivermectin MDA is precluded by co-endemicity with Loa loa. Vector control will likely be required as a supplemental intervention in these situations. Because biting by the black fly vectors is often a major nuisance in onchocerciasis afflicted communities, we hypothesized that community members might be mobilized to clear the breeding sites of the vegetation that represents the primary black fly larvae attachment point. We evaluated the effect of such a community based "slash and clear" intervention in multiple communities in Northern Uganda. Slash and Clear resulted in 89–99% declines in vector biting rates. The effect lasted up to 120 days post intervention. Slash and clear might represent an effective, inexpensive, community- based tool to supplement ivermectin distribution as a contributory method to eliminate onchocerciasis and prevent recrudescence. River blindness is one of the most important causes of morbidity in the developing world. The discovery of ivermectin and the decision by its manufacturer to donate the drug for river blindness spawned the development of programs to eliminate river blindness through mass treatment of afflicted populations. But ivermectin alone will not eliminate river blindness in much of Africa; additional interventions are necessary. We show that a simple community-based approach to controlling the black fly vector results in dramatic reductions in the vector population. Such a community-based approach to vector control will be compatible with the community-driven mass drug administration programs distributing ivermectin for onchocerciasis elimination in Africa. This should help reduce the time needed to obtain elimination and help prevent recrudescence once elimination is attained.
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影响因子：
158.5
作者：
GREENE, BM;TAYLOR, HR;WILLIAMS, PN
通讯作者：
WILLIAMS, PN
DOI：
10.1186/1475-2883-2-s1-s7
发表时间：
2003-10-24
期刊：
Filaria journal
影响因子：
--
作者：
Twum-Danso NA
通讯作者：
Twum-Danso NA
影响因子：
3.8
作者：
Traore, Mamadou O.;Sarr, Moussa D.;Remme, Jan H. F.
通讯作者：
Remme, Jan H. F.
影响因子：
2.2
作者：
Katabarwa MN;Walsh F;Habomugisha P;Lakwo TL;Agunyo S;Oguttu DW;Unnasch TR;Unoba D;Byamukama E;Tukesiga E;Ndyomugyenyi R;Richards FO
通讯作者：
Richards FO
影响因子：
56.9
作者：
CUPP, EW;BERNARDO, MJ;GREENE, BM
通讯作者：
GREENE, BM