COMT and ANKK1-Taq-Ia genetic polymorphisms influence visual working memory.
COMT and ANKK1-Taq-Ia genetic polymorphisms influence visual working memory.
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DOI：
10.1371/journal.pone.0055862
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Coslett HB
中科院分区：
文献类型：
--
作者：
Berryhill ME;Wiener M;Stephens JA;Lohoff FW;Coslett HB
复杂的认知任务，如视觉工作记忆（WM），涉及相互作用的大脑区域网络。几种神经递质，包括适当的多巴胺浓度，对WM性能很重要。许多基因多态性与认知任务表现的个体差异有关。例如，COMT编码儿茶酚-O-甲基转移酶，这种酶主要负责前额叶皮层中多巴胺的分解代谢。纹状体多巴胺功能与认知任务以及习惯学习有关，受DRD 2/ANKK 1基因复合物的Taq-Ia多态性影响;该基因影响纹状体中多巴胺受体的密度。在这里，我们调查了这些多态性的影响，WM任务需要维护的4或6个项目超过延迟持续时间为1或5秒。我们探讨了COMT和DRD 2/ANKK 1-Taq-Ia多态性对WM性能的主要影响和相互作用。对参与者进行了COMT（Val 158 Met）和DRD 2/ANKK 1-Taq-Ia（A1+、A1-）多态性基因分型。有一个显着的主效应的两个多态性。参与者的WM反应时间随着瓦尔负荷的增加而减慢，使得瓦尔/瓦尔纯合子的反应最慢，而Met/Met纯合子的反应最快。类似地，DRD 2/ANKK 1-Taq-Ia A1+组的WM反应时间比A1−组更慢，变化更大。COMT的主要作用仅在DRD 2/ANKK 1-Taq-Ia A1−组中明显。这些发现将WM表现与前额皮质中较慢的多巴胺能代谢以及纹状体中更大密度的多巴胺受体联系起来。
Complex cognitive tasks such as visual working memory (WM) involve networks of interacting brain regions. Several neurotransmitters, including an appropriate dopamine concentration, are important for WM performance. A number of gene polymorphisms are associated with individual differences in cognitive task performance. COMT, for example, encodes catechol-o-methyl transferase the enzyme primarily responsible for catabolizing dopamine in the prefrontal cortex. Striatal dopamine function, linked with cognitive tasks as well as habit learning, is influenced by the Taq-Ia polymorphism of the DRD2/ANKK1 gene complex; this gene influences the density of dopamine receptors in the striatum. Here, we investigated the effects of these polymorphisms on a WM task requiring the maintenance of 4 or 6 items over delay durations of 1 or 5 seconds. We explored main effects and interactions between the COMT and DRD2/ANKK1-Taq-Ia polymorphisms on WM performance. Participants were genotyped for COMT (Val158Met) and DRD2/ANKK1-Taq-Ia (A1+, A1−) polymorphisms. There was a significant main effect of both polymorphisms. Participants' WM reaction times slowed with increased Val loading such that the Val/Val homozygotes made the slowest responses and the Met/Met homozygotes were the fastest. Similarly, WM reaction times were slower and more variable for the DRD2/ANKK1-Taq-Ia A1+ group than the A1− group. The main effect of COMT was only apparent in the DRD2/ANKK1-Taq-Ia A1− group. These findings link WM performance with slower dopaminergic metabolism in the prefrontal cortex as well as a greater density of dopamine receptors in the striatum.
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影响因子：
2.6
作者：
Berryhill, Marian E.;Olson, Ingrid R.
通讯作者：
Olson, Ingrid R.
DOI：
10.1073/pnas.111134598
发表时间：
2001-06-05
影响因子：
11.1
作者：
Egan, MF;Goldberg, TE;Weinberger, DR
通讯作者：
Weinberger, DR
影响因子：
3.7
作者：
Diamond, Adele
通讯作者：
Diamond, Adele
影响因子：
10.6
作者：
Cools, Roshan;D'Esposito, Mark
通讯作者：
D'Esposito, Mark
影响因子：
3.2
作者：
Anderson DE;Bell TA;Awh E
通讯作者：
Awh E