Polymorphisms in the 5-HTTLPR gene mediate storage capacity of visual working memory.
Polymorphisms in the 5-HTTLPR gene mediate storage capacity of visual working memory.
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DOI：
10.1162/jocn_a_00207
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发表时间：
2012-05
影响因子：
3.2
通讯作者：
Awh E
中科院分区：
文献类型：
--
作者：
Anderson DE;Bell TA;Awh E
工作记忆是一个容量有限的系统，几乎渗透到从知觉到智力的所有认知水平。通过行为学、电生理学和神经影像学的研究，我们在理解这个容量有限的系统方面取得了实质性的进展。在目前的工作中，我们研究了遗传对WM储存能力的贡献。多项研究已经证明了5-羟色胺转运蛋白连锁多态性区域（5-HTTLPR）和认知之间的联系，其中与长（1）变体纯合的个体相比，在拥有该多态性的短（s）变体拷贝的个体中观察到更好的表现。我们预测WM性能的相同分布，使得I/I载波的估计容量应小于s/s和s/I载波。为了测量WM容量，我们实施了变化检测任务，这需要观察者在短的保持间隔内主动保持简要呈现的正方形的颜色和空间位置。与我们的预测一致，我们观察到s/s组和s/l组之间的WM表现相似，并且这些个体的表现优于l/l组。然后，我们讨论了5-羟色胺转运体系统的分布和WM和注意力之间的平行关系，以深入了解5-HTT多态性的变化如何导致WM储存能力的个体差异。
Working memory (WM) is a limited capacity system that permeates nearly all levels of cognition, ranging from perceptual awareness to intelligence. Through behavioral, electrophysiological, and neuroimaging work, substantial gains have been made in understanding this capacity-limited system. In the current work, we examined genetic contributions to the storage capacity of WM. Multiple studies have demonstrated a link between the serotonin transporter-linked polymorphic region (5-HTTLPR) and cognition, where better performance is observed in individuals possessing a copy of the short (s) variant of the polymorphism compared with individuals homozygous for the long (l) variant. We predicted the same profile in WM performance, such that estimated capacities of l/l carriers should be smaller than s/s and s/l carriers. To measure WM capacity, we implemented a change detection task, which requires observers to actively maintain the color and spatial location of briefly presented squares over a short retention interval. In line with our prediction, we observed similar WM performance between s/s and s/l groups, and these individuals performed better than the l/l group. We then discuss the distribution of the serotonin transporter system and parallels between WM and attention to provide insight into how variation in the 5-HTT polymorphism could lead to individual differences in the storage capacity of WM.
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影响因子：
2.5
作者：
D'Esposito, M;Postle, BR;Lease, J
通讯作者：
Lease, J
影响因子：
5.3
作者：
David, SP;Murthy, NV;Grasby, PM
通讯作者：
Grasby, PM
DOI：
10.1017/s1461145799001455
发表时间：
1999-06-01
影响因子：
4.8
作者：
Fallgatter, AJ;Jatzke, S;Lesch, KP
通讯作者：
Lesch, KP
影响因子：
4.6
作者：
Beevers, Christopher G.;Wells, Tony T.;McGeary, John E.
通讯作者：
McGeary, John E.
DOI：
10.1098/rspb.2008.1788
发表时间：
2009-05-22
期刊：
Proceedings. Biological sciences
影响因子：
--
作者：
Fox E;Ridgewell A;Ashwin C
通讯作者：
Ashwin C