Progression from gestational diabetes to type 2 diabetes in one region of Scotland: an observational follow-up study.
Progression from gestational diabetes to type 2 diabetes in one region of Scotland: an observational follow-up study.
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DOI：
10.1186/s12884-015-0457-8
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发表时间：
2015-02-03
影响因子：
3.1
通讯作者：
Evans JM
中科院分区：
文献类型：
--
作者：
Eades CE;Styles M;Leese GP;Cheyne H;Evans JM
本研究的目的是调查妊娠期糖尿病诊断后2型糖尿病（T2 D）的长期风险，并确定与T2 D风险增加相关的因素。采用观察性队列设计，随访1994年至2004年期间在苏格兰邓迪和安格斯地区的糖尿病产科诊所就诊的所有诊断为妊娠期糖尿病（GDM）的女性，以进行随后的T2 D诊断，如SCI-DC（一种综合糖尿病临床信息系统）所记录。研究中有164名女性接受了随访，直到2012年。四分之一的人在怀孕后患上T2 D，平均时间约为8年。与GDM后发生T2 D风险较高相关的因素包括妊娠期间体重增加、妊娠期间使用胰岛素、诊断GDM时糖化血红蛋白（HbA 1c）水平较高和空腹血糖。这些研究结果表明，有一个可行的时间窗口来防止从GDM进展到T2 D，并强调了那些风险最大的女性，因此应该优先进行预防性干预。
The aim of this study was to investigate long-term risk of type 2 diabetes (T2D) following a diagnosis of gestational diabetes and to identify factors that were associated with increased risk of T2D. An observational cohort design was used, following up all women diagnosed with gestational diabetes mellitus (GDM) attending a Diabetes Antenatal Clinic in the Dundee and Angus region of Scotland between 1994 and 2004 for a subsequent diagnosis of T2D, as recorded on SCI-DC (a comprehensive diabetes clinical information system). There were 164 women in the study who were followed up until 2012. One quarter developed T2D after a pregnancy with GDM in a mean time period of around eight years. Factors associated with a higher risk of developing T2D after GDM were increased weight during pregnancy, use of insulin during pregnancy, higher glycated haemoglobin (HbA1c) levels at diagnosis of GDM, and fasting blood glucose. These findings suggest there is a viable time window to prevent progression from GDM to T2D and highlights those women who are at the greatest risk and should therefore be prioritised for preventative intervention.
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影响因子：
105.7
作者：
Morris, AD;Boyle, DIR;MacDonald, TM
通讯作者：
MacDonald, TM
影响因子：
105.7
作者：
Gillies, Clare L.;Abrams, Keith R.;Khunti, Kamlesh
通讯作者：
Khunti, Kamlesh
DOI：
10.1016/0002-9378(91)90438-w
发表时间：
1991-10-01
影响因子：
9.8
作者：
CATALANO, PM;VARGO, KM;AMINI, SB
通讯作者：
AMINI, SB
影响因子：
3.2
作者：
Parsons, Judith;Ismail, Khalida;Forbes, Angus
通讯作者：
Forbes, Angus
DOI：
10.1016/s0002-9378(11)90676-0
发表时间：
1990-07-01
影响因子：
9.8
作者：
KJOS, SL;BUCHANAN, TA;MESTMAN, JH
通讯作者：
MESTMAN, JH