Genetic contribution to the phenotypic correlation between trait impulsivity and resting-state functional connectivity of the amygdala and its subregions
Genetic contribution to the phenotypic correlation between trait impulsivity and resting-state functional connectivity of the amygdala and its subregions
复制标题
杏仁核及其子区域的性状冲动性和静息态功能连接之间表型相关性的遗传贡献
DOI：
10.1016/j.neuroimage.2019.07.010
复制
发表时间：
2019-11
期刊：
影响因子：
5.7
通讯作者：
Zhou Yuan
中科院分区：
文献类型：
--
作者：
Zheng Dang;Chen Jie;Wang Xiaoming;Zhou Yuan
Trait impulsivity, a predisposition to respond to stimuli without regard for the potentially negative consequences, contributes to many maladaptive behaviors. Studies have shown that both genetic factors and interregional functional interactions underlie trait impulsivity. However, whether common genes contribute to both trait impulsivity and its neural basis is still unknown. This study investigated the phenotypic correlations between trait impulsivity and the resting-state functional connectivity (rsFC) of the amygdala as well as its subregions and the genetic contribution to the phenotypic correlations. By recruiting a sample of 292 twins in late adolescence and young adulthood, we found that trait impulsivity was positively correlated with the rsFC between the left full amygdala and the right dorsolateral prefrontal cortex (DLPFC). Further analyses on the subregions of the amygdala showed that trait impulsivity was positively correlated with the rsFCs between the left basolateral (BL) amygdala and both the right DLPFC and the right inferior frontal gyrus and with the rsFCs between the right superficial (SF) amygdala and both the dorsal anterior cingulate cortex and right anterior insula. Bivariate genetic modelling analyses found genetic overlaps between trait impulsivity and the rsFC of the left full amygdala or the left BL amygdala with the right DLPFC. The proportions of phenotypic associations accounted for by overlapping genes were 82% and 60%, respectively. These results provide evidence for the genetic overlap between trait impulsivity and the intrinsic brain functional connectivity centered at the amygdala and especially at its BL subregion.
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DOI：
10.1111/j.1749-6632.2003.tb07070.x
发表时间：
2003-04
影响因子：
5.2
作者：
J. Price
通讯作者：
J. Price
影响因子：
5.7
作者：
Kerestes R;Chase HW;Phillips ML;Ladouceur CD;Eickhoff SB
通讯作者：
Eickhoff SB
DOI：
10.1038/npp.2010.124
发表时间：
2010-11
期刊：
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
影响因子：
--
作者：
通讯作者：
--
影响因子：
5.7
作者：
Satterthwaite, Theodore D.;Wolf, Daniel H.;Loughead, James;Ruparel, Kosha;Elliott, Mark A.;Hakonarson, Hakon;Gur, Ruben C.;Gur, Raquel E.
通讯作者：
Gur, Raquel E.
影响因子：
3.7
作者：
Song XW;Dong ZY;Long XY;Li SF;Zuo XN;Zhu CZ;He Y;Yan CG;Zang YF
通讯作者：
Zang YF