Oxytocin neurons enable social transmission of maternal behaviour.
Oxytocin neurons enable social transmission of maternal behaviour.
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DOI：
10.1038/s41586-021-03814-7
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发表时间：
2021-08
期刊：
影响因子：
64.8
通讯作者：
Froemke RC
中科院分区：
文献类型：
--
作者：
Carcea I;Caraballo NL;Marlin BJ;Ooyama R;Riceberg JS;Mendoza Navarro JM;Opendak M;Diaz VE;Schuster L;Alvarado Torres MI;Lethin H;Ramos D;Minder J;Mendoza SL;Bair-Marshall CJ;Samadjopoulos GH;Hidema S;Falkner A;Lin D;Mar A;Wadghiri YZ;Nishimori K;Kikusui T;Mogi K;Sullivan RM;Froemke RC
产妇护理，包括由非亲生父母提供的护理，对后代的存活很重要。催产素是一种重要的母体激素，由下丘脑室旁核(PVN)释放。在小鼠中，催产素使听觉皮质的神经可塑性增强，从而使母亲能够识别幼崽的痛苦。然而，尚不清楚最初的父母经历如何促进下丘脑信号和皮质可塑性，以获得可靠的母亲护理。在这里，我们持续监测与经验丰富的母亲和幼崽共居的雌性处女鼠的行为。这种记录方法与来自处女室旁核的神经记录同步，包括催产素神经元。当处女被经验丰富的母亲征募到母体护理时，这些细胞被激活，她们将处女带入巢中，并展示取回幼崽的过程。处女视觉观察到母体取回，这激活了PVN催产素神经元，并促进了对位隔离。因此，啮齿动物可以通过社会传递获得母性行为，提供一种机制，通过内源性催产素使成年照顾者的大脑适应婴儿的需求。小鼠的行为研究和神经记录表明，处女小鼠可以通过催产素依赖机制获得母性行为。
Maternal care, including by non-biological parents, is important for offspring survival. Oxytocin, which is released by the hypothalamic paraventricular nucleus (PVN), is a critical maternal hormone. In mice, oxytocin enables neuroplasticity in the auditory cortex for maternal recognition of pup distress. However, it is unclear how initial parental experience promotes hypothalamic signalling and cortical plasticity for reliable maternal care. Here we continuously monitored the behaviour of female virgin mice co-housed with an experienced mother and litter. This documentary approach was synchronized with neural recordings from the virgin PVN, including oxytocin neurons. These cells were activated as virgins were enlisted in maternal care by experienced mothers, who shepherded virgins into the nest and demonstrated pup retrieval. Virgins visually observed maternal retrieval, which activated PVN oxytocin neurons and promoted alloparenting. Thus rodents can acquire maternal behaviour by social transmission, providing a mechanism for adapting the brains of adult caregivers to infant needs via endogenous oxytocin. Behavioural studies and neural recordings in mice show that virgin mice can acquire maternal behaviour through an oxytocin-dependent mechanism.
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影响因子：
2.5
作者：
LEE, PC
通讯作者：
LEE, PC
DOI：
10.1111/j.1749-6632.2011.06002.x
发表时间：
2011-01-01
期刊：
NEW PERSPECTIVES ON NEUROBEHAVIORAL EVOLUTION
影响因子：
--
作者：
Bonini, Luca;Ferrari, Pier Francesco
通讯作者：
Ferrari, Pier Francesco
影响因子：
5.5
作者：
Barrett, JF;Keat, N
通讯作者：
Keat, N
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y
影响因子：
25
作者：
Falkner AL;Grosenick L;Davidson TJ;Deisseroth K;Lin D
通讯作者：
Lin D