Binge drinking in adolescence predicts an atypical cortisol stress response in young adulthood.
Binge drinking in adolescence predicts an atypical cortisol stress response in young adulthood.
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DOI：
10.1016/j.psyneuen.2018.10.002
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发表时间：
2019-03
影响因子：
3.7
通讯作者：
Sandler I
中科院分区：
文献类型：
--
作者：
Hagan MJ;Modecki K;Moctezuma Tan L;Luecken L;Wolchik S;Sandler I
青春期是一个敏感的发育期，物质的使用可以对重要的生物系统产生长期的影响。新出现的横断面研究表明，有问题的饮酒可能与神经内分泌系统功能失调有关。目前的研究评估了青春期酗酒对童年经历过父母离婚的人(N=160；平均年龄=25.55，SD=1.22；46.9%女性；88.8%非西班牙裔白人)成年后皮质醇应激反应的预期影响。年轻人在青春期(15-19岁)完成了有效的问题饮酒措施，并在九年后的青壮年参与了一项标准化的社会压力任务。潜在增长模型是在结构方程模型框架内进行的。青春期大量饮酒与青年期皮质醇应激反应显著降低有关，控制了年轻人饮酒、性别、童年外化问题和社会经济地位。研究结果表明，青春期中后期的问题饮酒可能会对随后发育阶段的神经内分泌应激反应系统产生重要影响。
Adolescence is a sensitive developmental period in which substance use can exert long-term effects on important biological systems. Emerging cross-sectional research indicates that problematic alcohol consumption may be associated with dysregulated neuroendocrine system functioning. The current study evaluated the prospective effects of binge drinking in adolescence on cortisol stress reactivity in young adulthood among individuals who had experienced parental divorce in childhood (N=160; Mean age = 25.55, SD = 1.22; 46.9% Female; 88.8% White Non-Hispanic). Youth completed validated measures of problematic drinking during adolescence (aged 15-19) and participated in a standardized social stress task nine years later in young adulthood. Latent growth modeling was conducted within a structural equation modeling framework. Greater binge drinking during adolescence was associated with a significantly lower cortisol stress response in young adulthood, controlling for young adult drinking, sex, childhood externalizing problems, and socioeconomic status. Findings suggest problematic alcohol consumption during mid-late adolescence may have important effects on the neuroendocrine stress response system at subsequent developmental stages.
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