Fleischner Society Visual Emphysema CT Patterns Help Predict Progression of Emphysema in Current and Former Smokers: Results from the COPDGene Study.
Fleischner Society Visual Emphysema CT Patterns Help Predict Progression of Emphysema in Current and Former Smokers: Results from the COPDGene Study.
复制标题
Fleischner学会可视肺气肿CT模式有助于预测当前和以前吸烟者的肺气肿进展：来自COPD基因研究的结果
DOI：
10.1148/radiol.2020200563
复制
发表时间：
2021-03
期刊：
影响因子：
19.7
通讯作者：
Lynch DA
中科院分区：
文献类型：
--
作者：
El Kaddouri B;Strand MJ;Baraghoshi D;Humphries SM;Charbonnier JP;van Rikxoort EM;Lynch DA
视觉肺气肿类型和随后的疾病进展之间的相关性可能为肺气肿的治疗试验提供一种丰富研究人群的方法。目的：探讨肺气肿视力亚型与肺气肿进展及气体捕获的潜在关系。2008至2011年间，有或没有慢性阻塞性肺疾病(COPD)的现任和既往吸烟者参加了COPD(COPD基因)前瞻性遗传流行病学研究(ClinicalTrials.gov标识符：NCT02445183)，并在基线、定量吸气和呼气CT以及5年时对他们的Fleischner Society视觉CT评分进行了评估。他们还在基线CT和5年时进行了肺功能测试。因变量是吸气相第15百分位数的肺密度(根据肺体积调整)作为肺气肿的量度，以及呼气CT上密度小于−856HU的肺体积的百分比作为空气滞留的量度。统计分析使用了线性混合模型，调整了年龄、身高、性别、种族、吸烟状况和扫描仪制造。共有4166名参与者(平均年龄60岁±9岁[标准差]；2091名男性[50%])接受了评估。在COPD参与者(1655名参与者，40%)中，基线CT显示轻度、中度和融合性肺气肿的患者的肺密度平均下降分别为4.6g/L±1.1(P<；.001)、6.7g/L±1.1(P<；.001)和6.4g/L±1.2(P<；.001)，而有微量肺气肿的患者为2.4g/L±1.3(P<；.001)。在无COPD的受试者中，基线CT上有轻度和中度肺气肿的受试者肺密度分别下降3.6g/L±1.0(P<；.001)和3.1g/L±1.6(P<；.001)，而有少量肺气肿的受试者平均肺密度下降1.8g/L±1.0(P<；.001)。基线CT上实质性肺气肿的类型是参与者中继发肺气肿进展的独立预测因子，这些参与者现在或以前吸烟，有或没有慢性阻塞性肺疾病。在患有和不患有慢性阻塞性肺疾病的现任和既往吸烟者中，Fleischner Society的CT肺气肿视觉模式有助于预测肺气肿和气体捕获的进展。
The correlation between visual emphysema patterns and subsequent progression of disease may provide a way to enrich a study population for treatment trials of emphysema. To evaluate the potential relationship between emphysema visual subtypes and progression of emphysema and gas trapping. Current and former smokers with and without chronic obstructive pulmonary disease (COPD) enrolled in the prospective Genetic Epidemiology of COPD (COPDGene) study (ClinicalTrials.gov identifier: NCT02445183) between 2008 and 2011 had their Fleischner Society visual CT scores assessed at baseline, quantitative inspiratory, and expiratory CT and at 5 years. They also underwent pulmonary function testing at baseline CT and at 5 years. The dependent variables were inspiratory lung density at 15th percentile (adjusted for lung volume) as a measure of emphysema and percentage of lung volume with attenuation less than −856 HU at expiratory CT as a measure of air trapping. Statistical analysis used a linear mixed model, adjusted for age, height, sex, race, smoking status, and scanner make. A total of 4166 participants (mean age, 60 years ± 9 [standard deviation]; 2091 [50%] men) were evaluated. In participants with COPD (1655 participants, 40%), those with visual presence of mild, moderate, and confluent emphysema at baseline CT showed a mean decline in lung density of 4.6 g/L ± 1.1 (P < .001), 6.7 g/L ± 1.1 (P < .001), and 6.4 g/L ± 1.2 (P < .001), respectively, compared with 2.4 g/L ± 1.3 (P < .001) for those with trace emphysema. For participants without COPD, those with visual presence of mild and moderate emphysema at baseline CT showed a mean decline in lung density of 3.6 g/L ± 1.0 (P < .001) and 3.1 g/L ± 1.6 (P < .001), respectively, compared with 1.8 g/L ± 1.0 (P < .001) for those with trace emphysema. The pattern of parenchymal emphysema at baseline CT was an independent predictor of subsequent progression of emphysema in participants who are current or former cigarette smokers with and without chronic obstructive pulmonary disease. In current and former smokers with and without chronic obstructive pulmonary disease, the Fleischner Society visual pattern of emphysema at CT helped predict progression of emphysema and gas trapping.
登录
查看更多内容
有或没有慢性阻塞性肺部疾病的受试者中气流阻塞与肺气肿，空气陷阱和气道的定量CT测量之间的关系。
DOI：
10.2214/ajr.12.10102
发表时间：
2013-09
期刊：
AJR. American journal of roentgenology
影响因子：
--
作者：
Schroeder JD;McKenzie AS;Zach JA;Wilson CG;Curran-Everett D;Stinson DS;Newell JD Jr;Lynch DA
通讯作者：
Lynch DA
影响因子：
19.7
作者：
Hackx, Maxime;Bankier, Alexander A.;Gevenois, Pierre Alain
通讯作者：
Gevenois, Pierre Alain
影响因子：
9.6
作者：
Diaz, Alejandro A.;Strand, Matthew;Washko, George R.
通讯作者：
Washko, George R.
影响因子：
10
作者：
Parr, D. G.;Stoel, B. C.;Stockley, R. A.
通讯作者：
Stockley, R. A.
DOI：
10.1164/ajrccm.159.3.9805067
发表时间：
1999-03-01
影响因子：
24.7
作者：
Coxson, HO;Rogers, RM;Hogg, JC
通讯作者：
Hogg, JC