L-Arginine Increases Postprandial Circulating GLP-1 and PYY Levels in Humans.
L-Arginine Increases Postprandial Circulating GLP-1 and PYY Levels in Humans.
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L-精氨酸增加了人类的餐后循环GLP-1和PYY水平。
DOI：
10.1002/oby.22323
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发表时间：
2018-11
期刊：
影响因子：
--
通讯作者：
Murphy KG
中科院分区：
文献类型：
--
作者：
Amin A;Neophytou C;Thein S;Martin NM;Alamshah A;Spreckley E;Bloom SR;Murphy KG
与其他营养素相比，蛋白质的饱腹感效果已经得到了很好的描述，并被认为部分是通过肠道激素释放来调节的。以往的研究表明，口服L精氨酸在啮齿类动物体内和体外都具有促分泌剂的作用。本文研究了L精氨酸对人体胃肠激素释放的影响。这一假设在两项不同的研究中得到了验证。第一项研究评估了健康受试者口服L精氨酸的耐受性。第二项研究评估了口服L精氨酸对随意餐后胃肠激素释放的影响。受试者以随机双盲方式给予L精氨酸、甘氨酸(对照氨基酸)或赋形剂对照组。L-精氨酸在17.1mmol时耐受性良好，可刺激自由餐后血浆GLP-1(P <； 0.001)和PYY(P <； 0.001)的释放。饮食日记显示L-精氨酸治疗后能量摄入减少，尤其是脂肪摄入减少。L精氨酸配餐可显著升高健康受试者的GLP-1和PYY水平。需要进一步研究L-精氨酸是否在抑制食欲和食物摄入方面有作用。
The satiating effect of protein compared with other nutrients has been well described and is thought to be mediated, in part, by gut hormone release. Previously, it has been shown that oral L‐arginine acts as a GLP‐1 secretagogue both in vitro and in vivo in rodents. Here, the effect of L‐arginine on gut hormone release in humans was investigated. The hypothesis was tested in two separate studies. The first study assessed the tolerability of oral L‐arginine in healthy human subjects. The second study assessed the effect of oral L‐arginine on gut hormone release following an ad libitum meal. Subjects were given L‐arginine, glycine (control amino acid), or vehicle control in a randomized double‐blind fashion. At a dose of 17.1 mmol, L‐arginine was well tolerated and stimulated the release of plasma GLP‐1 (P < 0.05) and PYY (P < 0.001) following an ad libitum meal. Food diaries showed a trend toward lower energy intake and particularly fat intake following L‐arginine treatment. L‐arginine can significantly elevate GLP‐1 and PYY in healthy human volunteers in combination with a meal. Further work is required to investigate whether L‐arginine may have utility in the suppression of appetite and food intake.
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DOI：
10.1111/dom.12644
发表时间：
2016-05
期刊：
Diabetes, obesity & metabolism
影响因子：
--
作者：
Alamshah A;McGavigan AK;Spreckley E;Kinsey-Jones JS;Amin A;Tough IR;O'Hara HC;Moolla A;Banks K;France R;Hyberg G;Norton M;Cheong W;Lehmann A;Bloom SR;Cox HM;Murphy KG
通讯作者：
Murphy KG
影响因子：
5.5
作者：
Jordi, Josua;Herzog, Brigitte;Verrey, Francois
通讯作者：
Verrey, Francois
影响因子：
4.8
作者：
Habib, Abdella M.;Richards, Paul;Gribble, Fiona M.
通讯作者：
Gribble, Fiona M.
影响因子：
4
作者：
ELLIOTT, RM;MORGAN, LM;MARKS, V
通讯作者：
MARKS, V
影响因子：
7.1
作者：
HANNAH, JS;DUBEY, AK;HANSEN, BC
通讯作者：
HANSEN, BC