Genome-free viral capsids as multivalent carriers for taxol delivery.
Genome-free viral capsids as multivalent carriers for taxol delivery.
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DOI：
10.1002/anie.200902426
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发表时间：
2009
影响因子：
16.6
通讯作者：
Francis, Matthew B.
中科院分区：
文献类型：
--
作者：
Wu, Wesley;Hsiao, Sonny C.;Carrico, Zachary M.;Francis, Matthew B.
化疗中使用的药物主要通过针对细胞分裂机制发挥作用，1并且在一定程度上优先影响癌细胞，因为它们的增殖率异常高。不幸的是，许多健康细胞也受到这些治疗的影响，导致副作用，导致患者严重不适。新兴方法试图通过针对实体瘤中发现的特定特征，将药物集中在癌症组织上。 2 作为这些方法的一个有前景的子集，大分子药物递送旨在将许多小分子药物和靶向基团附着到大型结构上。 3 由于肿瘤血管系统的独特特征，许多此类运载工具的体积增大，4 以及通过增强的渗透和保留效应实现一定程度的被动靶向，因此循环时间延长。 5 作为一个额外的好处，大分子足够大，可以显示活性靶向配体的多个副本，以增强结合亲合力，6 还可以提供多个货物附着位点，以增加可递送的有效负载量。目前正在研究许多大分子用作药物载体。聚合物疗法基于多种材料，例如聚乙二醇 (PEG) 7 或甲基丙烯酸羟丙酯 8，允许设计具有多种递送行为的载体。树枝状聚合物也具有这些特性，并具有受控的多分散性和球形形状的额外优势。 9 脂质体 10 和胶束 11 系统具有高货物装载量，但可能难以储存，并且可能会出现不规则的释放和分布曲线。无机纳米粒子12和碳纳米管13作为运载工具都具有独特的特性，但必须经过彻底的测试以评估其生物相容性。基于蛋白质的系统，例如最近使用的血清白蛋白，14 本质上具有生物相容性，但大多数当前系统不表现出任何形式的主动靶向。作为一个值得注意的例外，嗜热热激蛋白笼经过改造，可容纳多达 24 个阿霉素分子，并在其外表面展示靶向肽插入物。 15
Drugs used in chemotherapy predominantly act by targeting the mechanisms of cell division, 1 and to an extent, preferentially affect cancer cells because of their unusually high proliferation rates. Unfortunately, many healthy cells are also affected by these treatments, resulting in side effects that cause substantial discomfort for the patient. Emerging methods seek to focus the delivery of drugs on cancer tissue by targeting specific characteristics found in solid tumors. 2 As a promising subset of these approaches, macromolecular drug delivery seeks to attach many small molecule drugs and targeting groups to large structures. 3 Many of these delivery vehicles experience prolonged circulation time because of their increased size, 4 as well as a degree of passive targeting through the enhanced permeation and retention effect, arising from unique characteristics of tumor vasculature. 5 As an additional benefit, macromolecules are large enough to display multiple copies of active targeting ligands to enhance binding avidity, 6 and can also provide multiple cargo attachment sites to increase the amount of payload that can be delivered.Many macromolecules are currently being studied for use as drug carriers. Polymer therapeutics are based on a wide variety of materials, such as poly-ethylene glycol (PEG) 7 or hydroxypropyl methacrylate, 8 allowing carriers with a wide range of delivery behaviors to be designed. Dendritic polymers also offer these properties, with the added advantage of controlled polydispersity and globular shape. 9 Liposomal10 and micellular11 systems feature high cargo loadings, but can be difficult to store and can suffer from irregular release and distribution profiles. Inorganic nanoparticles12 and carbon nanotubes13 both feature unique properties as delivery vehicles, but must undergo thorough testing to evaluate their biocompatibility. Protein based systems, such as the recent usage of serum albumin, 14 are inherently biocompatible, but most current systems do not exhibit any form of active targeting. As a notable exception, thermophilic heat shock protein cages have been modified to house up to 24 doxorubicin molecules and display targeting peptide inserts on their exterior surface. 15
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影响因子：
10.8
作者：
Hooker, Jacob M.;Datta, Ankona;Francis, Matthew B.
通讯作者：
Francis, Matthew B.
影响因子：
78.5
作者：
Chabner, BA;Roberts, TG
通讯作者：
Roberts, TG
影响因子：
4.9
作者：
Flenniken, ML;Liepold, LO;Douglas, T
通讯作者：
Douglas, T
影响因子：
8.8
作者：
Duncan, R;Kopeckova-Rejmanova, P;Strohalm, J;Hume, I;Cable, H C;Pohl, J;Lloyd, J B;Kopecek, J
通讯作者：
Kopecek, J
影响因子：
7.3
作者：
DEUTSCH, HM;GLINSKI, JA;ZALKOW, LH
通讯作者：
ZALKOW, LH