The California Breast Cancer Survivorship Consortium (CBCSC): prognostic factors associated with racial/ethnic differences in breast cancer survival.
The California Breast Cancer Survivorship Consortium (CBCSC): prognostic factors associated with racial/ethnic differences in breast cancer survival.
复制标题
DOI：
10.1007/s10552-013-0260-7
复制
发表时间：
2013-10
影响因子：
2.3
通讯作者：
Sposto, Richard
中科院分区：
文献类型：
--
作者：
Wu, Anna H.;Gomez, Scarlett Lin;Vigen, Cheryl;Kwan, Marilyn L.;Keegan, Theresa H. M.;Lu, Yani;Shariff-Marco, Salma;Monroe, Kristine R.;Kurian, Allison W.;Cheng, Iona;Caan, Bette J.;Lee, Valerie S.;Roh, Janise M.;Sullivan-Halley, Jane;Henderson, Brian E.;Bernstein, Leslie;John, Esther M.;Sposto, Richard
美国乳腺癌患者死亡率的种族/民族差异是有据可查的。我们对生活方式因素对疾病预后的贡献的了解主要基于非拉丁裔白人，对拉丁裔、非裔美国人和亚裔美国女性的了解有限。为了消除这一认识差距，加州乳腺癌生存联盟(CBCSC)统一和汇集了总部设在加利福尼亚州的六项乳腺癌研究的访谈信息(如人口统计、乳腺癌家族史、生育情况、吸烟、饮酒情况)，并收集了相应的癌症登记数据(临床特征、死亡率)，在1993至2007年间，共有12 210名患者(非拉丁裔白人6 501人、非裔美国人2 060人、拉丁裔2 032人、亚裔1 505人、其他种族/族裔112人)被诊断为原发性浸润性乳腺癌。总共观察到3,047例死亡(1,570例乳腺癌患者)，平均随访8.3(3.5)年。COX比例风险回归模型适用于估计总体死亡率和乳腺癌特异性死亡率的风险比(HR)和95%可信区间(CI)。与非拉丁裔白人相比，在调整了年龄、肿瘤特征和选择的生活方式因素后，非裔美国人乳腺癌特异性死亡率的HR为1.13(95%CI，0.97~1.33)，拉丁裔美国人为0.84(95%CI，0.70~1.00)，亚裔美国人为0.60(95%CI，0.37~0.97)。CBCSC代表了来自加利福尼亚州的一大批种族/民族多样化的乳腺癌患者。这一队列将使分析能够联合考虑各种临床、生活方式和背景因素，试图解释乳腺癌预后的长期差异。
Racial/ethnic disparities in mortality among US breast cancer patients are well-documented. Our knowledge of the contribution of lifestyle factors to disease prognosis is based primarily on non-Latina Whites and is limited for Latina, African American and Asian American women. To address this knowledge gap, the California Breast Cancer Survivorship Consortium (CBCSC) harmonized and pooled interview information (e.g., demographics, family history of breast cancer, parity, smoking, alcohol consumption) from six California-based breast cancer studies and assembled corresponding cancer registry data (clinical characteristics, mortality), resulting in 12,210 patients (6,501 non-Latina Whites, 2,060 African Americans, 2,032 Latinas, 1,505 Asian Americans, 112 other race/ethnicity) diagnosed with primary invasive breast cancer between 1993 and 2007. In total, 3,047 deaths (1,570 breast cancer-specific) were observed with a mean (SD) follow-up of 8.3 (3.5) years. Cox-proportional hazards regression models were fit to data to estimate hazards ratios (HR) and 95% confidence intervals (CI) for overall and breast cancer-specific mortality. Compared with non-Latina Whites, the HR of breast cancer-specific mortality was 1.13 (95% CI, 0.97-1.33) for African Americans, 0.84 (95% CI, 0.70-1.00) for Latinas, and 0.60 (95% CI, 0.37-0.97) for Asian Americans after adjustment for age, tumor characteristics, and select lifestyle factors. The CBCSC represents a large and racially/ethnically diverse cohort of breast cancer patients from California. This cohort will enable analyses to jointly consider a variety of clinical, lifestyle, and contextual factors in attempting to explain the long-standing disparities in breast cancer outcomes.
登录
查看更多内容
影响因子：
3.8
作者：
Keegan, Theresa H. M.;Milne, Roger L.;Andrulis, Irene L.;Chang, Ellen T.;Sangaramoorthy, Meera;Phillips, Kelly-Anne;Giles, Graham G.;Goodwin, Pamela J.;Apicella, Carmel;Hopper, John L.;Whittemore, Alice S.;John, Esther M.
通讯作者：
John, Esther M.
影响因子：
2.3
作者：
Gomez, Scarlett Lin;Glaser, Sally L.;Satariano, William A.
通讯作者：
Satariano, William A.
影响因子：
6.4
作者：
Braithwaite, Dejana;Tammemagi, C. Martin;Esserman, Laura
通讯作者：
Esserman, Laura
影响因子：
45.3
作者：
Jatoi, I;Anderson, WF;Devesa, SS
通讯作者：
Devesa, SS
影响因子：
3.8
作者：
Abrahamson, Page E.;Gammon, Marilie D.;Coates, Ralph J.
通讯作者：
Coates, Ralph J.