Chronic Alcohol Exposure Among People Living with HIV Is Associated with Innate Immune Activation and Alterations in Monocyte Phenotype and Plasma Cytokine Profile.
Chronic Alcohol Exposure Among People Living with HIV Is Associated with Innate Immune Activation and Alterations in Monocyte Phenotype and Plasma Cytokine Profile.
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HIV患者的慢性酒精暴露与先天免疫激活以及单核细胞表型和血浆细胞因子特征的改变有关。
DOI：
10.3389/fimmu.2022.867937
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发表时间：
2022
影响因子：
7.3
通讯作者：
Lancioni CL
中科院分区：
文献类型：
--
作者：
Underwood ML;Park B;Uebelhoer LS;Gu G;Kunkel LE;Korthuis PT;Cook RR;Sekaly RP;Ribeiro SP;Lancioni CL
尽管在抗逆转录病毒治疗方面取得了进展，但在艾滋病毒病毒载量得到良好控制的个人中继续观察到慢性免疫激活，并与非艾滋病有关，这决定了艾滋病毒携带者的发病率。酒精使用障碍影响了相当大比例的艾滋病毒携带者，众所周知，酒精暴露会损害肠道上皮，这可能会增加病原体及其分子产物的移位，推动系统免疫激活和调节失调。这项研究的目的是确定与没有长期接触酒精或其他滥用物质的艾滋病毒携带者(n=29)相比，患有控制良好的病毒载量的艾滋病毒携带者(n=23)是否表现出系统免疫激活、肠道损伤和微生物易位的证据，这些成年人也患有酒精使用障碍，并合并和不合并丙型肝炎病毒感染。还检查了为期1个月的酒精使用障碍治疗干预的影响。酒精使用障碍与先天免疫激活的证据，单核细胞表型的改变，包括Toll样受体4的表达增加，Toll样受体4的刺激配体负荷增加，以及血浆细胞因子信号的改变，最显著的是可溶性CD40配体和转化生长因子β的升高有关。与酒精相关的免疫激活在合并感染丙型肝炎病毒的个体中更为明显。虽然为期1个月的酒精使用障碍治疗干预并没有导致免疫激活的询问指标显著减少，但我们的发现表明，长期酒精暴露是艾滋病毒携带者慢性免疫激活和调节失调的主要可改变的风险因素。
Despite advances in antiretroviral therapy, chronic immune activation continues to be observed among individuals with well-controlled HIV viral loads, and is associated with non-AIDS defining morbidities among people living with HIV. Alcohol use disorder impacts a significant proportion of individuals living with HIV, and alcohol exposure is known to damage the intestinal epithelium which may increase translocation of pathogens and their molecular products, driving systemic immune activation and dysregulation. The aim of this study was to determine if adults living with HIV with well-controlled viral loads, who also suffer from alcohol use disorder with and without hepatitis C virus co-infection (n=23), exhibit evidence of advanced systemic immune activation, intestinal damage, and microbial translocation, as compared to adults living with HIV who are not exposed to chronic alcohol or other substances of abuse (n=29). The impact of a 1-month intervention to treat alcohol-use disorder was also examined. Alcohol-use disorder was associated with evidence of advanced innate immune activation, alterations in monocyte phenotype including increased expression of Toll-like receptor 4, increased burden of stimulatory ligands for Toll-like receptor 4, and alterations in plasma cytokine signature, most notably elevations in soluble CD40 ligand and transforming growth factor beta. Alcohol-associated immune activation was more pronounced among individuals with hepatitis C virus co-infection. Although the 1-month intervention to treat alcohol use disorder did not result in significant reductions in the interrogated indicators of immune activation, our findings suggest that chronic alcohol exposure is a major modifiable risk factor for chronic immune activation and dysregulation among people-living with HIV.
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影响因子：
5.6
作者：
Aloui C;Prigent A;Sut C;Tariket S;Hamzeh-Cognasse H;Pozzetto B;Richard Y;Cognasse F;Laradi S;Garraud O
通讯作者：
Garraud O
影响因子：
3.7
作者：
Ancuta, P;Kuntsman, KJ;Gabuzda, D
通讯作者：
Gabuzda, D
影响因子：
9.3
作者：
Davidson DC;Jackson JW;Maggirwar SB
通讯作者：
Maggirwar SB
DOI：
10.1111/acer.13527
发表时间：
2018-01-01
期刊：
ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH
影响因子：
--
作者：
Donnadieu-Rigole, Helene;Pansu, Nathalie;Dunyach-Remy, Catherine
通讯作者：
Dunyach-Remy, Catherine
DOI：
10.1007/s00018-020-03656-y
发表时间：
2021-03
期刊：
Cellular and molecular life sciences : CMLS
影响因子：
--
作者：
Ciesielska A;Matyjek M;Kwiatkowska K
通讯作者：
Kwiatkowska K