The signaling role of CD40 ligand in platelet biology and in platelet component transfusion.
The signaling role of CD40 ligand in platelet biology and in platelet component transfusion.
复制标题
DOI：
10.3390/ijms151222342
复制
发表时间：
2014-12-03
影响因子：
5.6
通讯作者：
Garraud O
中科院分区：
文献类型：
--
作者：
Aloui C;Prigent A;Sut C;Tariket S;Hamzeh-Cognasse H;Pozzetto B;Richard Y;Cognasse F;Laradi S;Garraud O
CD40配体(CD40L)是一种跨膜分子，在天然免疫和获得性免疫的细胞信号转导中具有重要意义。它由多种细胞表达，但主要由活化的T淋巴细胞和血小板表达。CD40L可被切割成具有细胞因子样活性的可溶性形式(SCD40L)。这两种形式都能与几种受体结合，包括CD40。这种相互作用是抗原特异性免疫反应所必需的。此外，CD40L和sCD40L参与了炎症和一系列免疫相关和血管病变。可溶性CD40L主要由血小板活化、脱颗粒和切割后产生，这可能会给输血带来困难。可溶性CD40L参与不良输血事件，包括输血相关急性肺损伤(TRALI)。尽管为输血而设计的血小板储存是在无菌条件下进行的，但在没有已知激动剂的情况下，血小板被激活并释放sCD40L。最近，蛋白质组学研究发现了浓缩血小板中激活的信号通路。在自动扩增环中，可溶性CD40L是血小板激活的一个很好的候选者。本文就CD40L在生理和病理条件下的免疫调节作用作一综述。我们将重点介绍CD40L与其不同受体结合后激活的主要信号通路。
The CD40 ligand (CD40L) is a transmembrane molecule of crucial interest in cell signaling in innate and adaptive immunity. It is expressed by a variety of cells, but mainly by activated T-lymphocytes and platelets. CD40L may be cleaved into a soluble form (sCD40L) that has a cytokine-like activity. Both forms bind to several receptors, including CD40. This interaction is necessary for the antigen specific immune response. Furthermore, CD40L and sCD40L are involved in inflammation and a panoply of immune related and vascular pathologies. Soluble CD40L is primarily produced by platelets after activation, degranulation and cleavage, which may present a problem for transfusion. Soluble CD40L is involved in adverse transfusion events including transfusion related acute lung injury (TRALI). Although platelet storage designed for transfusion occurs in sterile conditions, platelets are activated and release sCD40L without known agonists. Recently, proteomic studies identified signaling pathways activated in platelet concentrates. Soluble CD40L is a good candidate for platelet activation in an auto-amplification loop. In this review, we describe the immunomodulatory role of CD40L in physiological and pathological conditions. We will focus on the main signaling pathways activated by CD40L after binding to its different receptors.
登录
查看更多内容
影响因子：
10.4
作者：
Choi, W. -S.;Jeon, O. -H.;Kim, D. -S.
通讯作者：
Kim, D. -S.
影响因子：
2.9
作者：
Cognasse, Fabrice;Hamzeh-Cognasse, Hind;Garraud, Olivier
通讯作者：
Garraud, Olivier
影响因子：
2.6
作者：
Cognasse, Fabrice;Hameh-Cognasse, Hind;Garraud, Olivier
通讯作者：
Garraud, Olivier
影响因子：
2.9
作者：
Cognasse, Fabrice;Boussoulade, Francoise;Garraud, Olivier
通讯作者：
Garraud, Olivier
影响因子：
20.3
作者：
Canault, Matthias;Duerschmied, Daniel;Wagner, Denisa D.
通讯作者：
Wagner, Denisa D.