An in vivo rabbit model for the evaluation of antimicrobial peripherally inserted central catheter to reduce microbial migration and colonization as compared to an uncoated PICC.
An in vivo rabbit model for the evaluation of antimicrobial peripherally inserted central catheter to reduce microbial migration and colonization as compared to an uncoated PICC.
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DOI：
10.1155/2012/921617
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发表时间：
2012
影响因子：
--
通讯作者：
Olson ME
中科院分区：
文献类型：
--
作者：
Allan ND;Giare-Patel K;Olson ME
感染是与血管内装置相关的主要并发症，当导管被微生物定植时，这些感染就会发生。为了解决这一问题，医疗设备制造商试图为医疗机构提供抗菌医疗设备，以防止或减少细菌的定植。为了充分评估这些装置，需要一个体内模型来准确评估抗菌装置在临床环境中的性能。本文提出的模型旨在模拟皮下隧道环境，以评估涂覆氯己定技术的抗菌外周插入中心导管（PICC）与未涂覆的PICC相比，减少微生物迁移和定植的能力。将3个对照组、未包衣PICCs和3个包衣PICCs样本通过手术隧道置入雌性新西兰大白兔背部。植入时，植入部位受到金黄色葡萄球菌的侵袭。动物被评估到30天，然后被处死。对导管和周围组织进行完整的整体解剖和评估表明，与未经处理的标准导管相比，氯己定涂层导管能够显著减少微生物定植并防止微生物迁移。
Infection is the leading complication associated with intravascular devices, and these infections develop when a catheter becomes colonized by microorganisms. To combat this issue, medical device manufacturers seek to provide healthcare facilities with antimicrobial medical devices to prevent or reduce the colonization. In order to adequately evaluate these devices, an in vivo model is required to accurately assess the performance of the antimicrobial devices in a clinical setting. The model presented herein was designed to provide a simulation of the subcutaneous tunnel environment to evaluate the ability of an antimicrobial peripherally inserted central catheter (PICC), coated with chlorhexidine based technology, to reduce microbial migration and colonization compared to an uncoated PICC. Three samples of control, uncoated PICCs and three samples of coated PICCs were surgically tunneled into the backs of female New Zealand White rabbits. The insertion sites were then challenged with Staphylococcus aureus at the time of implantation. Animals were evaluated out to thirty days and sacrificed. Complete en bloc dissection and evaluation of the catheter and surrounding tissue demonstrated that the chlorhexidine coated catheter was able to significantly reduce microbial colonization and prevent microbial migration as compared to the standard, un-treated catheter.
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影响因子：
120.7
作者：
PITTET, D;TARARA, D;WENZEL, RP
通讯作者：
WENZEL, RP
影响因子：
9.4
作者：
Ceri, H;Olson, ME;Buret, A
通讯作者：
Buret, A
影响因子：
8.8
作者：
OLSON, ME;LAM, K;COSTERTON, JW
通讯作者：
COSTERTON, JW
影响因子：
8
作者：
Sengupta A;Lehmann C;Diener-West M;Perl TM;Milstone AM
通讯作者：
Milstone AM
影响因子：
6.4
作者：
RADD, I;COSTERTON, W;BODEY, GP
通讯作者：
BODEY, GP