Inferring the ecological niche of bat viruses closely related to SARS-CoV-2 using phylogeographic analyses of Rhinolophus species.
Inferring the ecological niche of bat viruses closely related to SARS-CoV-2 using phylogeographic analyses of Rhinolophus species.
复制标题
DOI：
10.1038/s41598-021-93738-z
复制
发表时间：
2021-07-12
影响因子：
4.6
通讯作者：
Csorba G
中科院分区：
文献类型：
--
作者：
Hassanin A;Tu VT;Curaudeau M;Csorba G
严重急性呼吸系统综合征冠状病毒2（SARS-CoV-2）是2019年冠状病毒病（COVID-19）大流行的病原体。到目前为止，已在四种蝙蝠中报告了与SARS-CoV-2密切相关的病毒：尖菊头蝠，菊头蝠，马来菊头蝠和沙美菊头蝠。在这里，我们分析了343个序列的线粒体细胞色素c氧化酶亚基1基因（CO 1）的地理参照蝙蝠的四个菊头蝠物种确定为水库的病毒密切相关的SARS冠状病毒-2。单倍型网络的构建，以调查东南亚和中国的蝙蝠种群之间的遗传多样性模式。没有发现强烈的地理结构的四种菊头蝠，表明高扩散能力。利用最近发现蝙蝠病毒的四个地点和蝙蝠表现出与病毒阳性蝙蝠相同的CO 1单倍型的地点，预测了与SARS-CoV-2密切相关的蝙蝠病毒的生态位。从蝙蝠病毒的检测地点推断出与SARS-CoV相关的蝙蝠病毒的生态位。结果表明，SARS-CoV 2相关蝙蝠病毒的生态位包括东南亚大陆的几个地区，而SARS-CoV相关蝙蝠病毒的生态位主要局限于中国。与这些结果一致，老挝、越南、柬埔寨和泰国的人口似乎比东南亚其他国家受COVID-19大流行的影响要小得多。在两个生态位之间的气候过渡带（云南南部、老挝北方、越南北方），高度分化的病毒之间更容易发生基因组重组。考虑到有限的数据和重组蝙蝠冠状病毒作为人类新流行病来源的风险，这些地区的蝙蝠种群应该受到监测。
The Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) is the causal agent of the coronavirus disease 2019 (COVID-19) pandemic. To date, viruses closely related to SARS-CoV-2 have been reported in four bat species: Rhinolophus acuminatus, Rhinolophus affinis, Rhinolophus malayanus, and Rhinolophus shameli. Here, we analysed 343 sequences of the mitochondrial cytochrome c oxidase subunit 1 gene (CO1) from georeferenced bats of the four Rhinolophus species identified as reservoirs of viruses closely related to SARS-CoV-2. Haplotype networks were constructed in order to investigate patterns of genetic diversity among bat populations of Southeast Asia and China. No strong geographic structure was found for the four Rhinolophus species, suggesting high dispersal capacity. The ecological niche of bat viruses closely related to SARS-CoV-2 was predicted using the four localities in which bat viruses were recently discovered and the localities where bats showed the same CO1 haplotypes than virus-positive bats. The ecological niche of bat viruses related to SARS-CoV was deduced from the localities where bat viruses were previously detected. The results show that the ecological niche of bat viruses related to SARS-CoV2 includes several regions of mainland Southeast Asia whereas the ecological niche of bat viruses related to SARS-CoV is mainly restricted to China. In agreement with these results, human populations in Laos, Vietnam, Cambodia, and Thailand appear to be much less affected by the COVID-19 pandemic than other countries of Southeast Asia. In the climatic transitional zone between the two ecological niches (southern Yunnan, northern Laos, northern Vietnam), genomic recombination between highly divergent viruses is more likely to occur. Considering the limited data and the risk of recombinant bat-CoVs emergence as the source of new pandemics in humans, the bat populations in these regions should be under surveillance.
登录
查看更多内容
中国多种蝙蝠α冠状病毒和β冠状病毒的鉴定为冠状病毒相关疾病的进化和起源提供了新的见解
影响因子：
5.2
作者：
Han, Yelin;Du, Jiang;Jin, Qi
通讯作者：
Jin, Qi
影响因子：
1.6
作者：
Ith, Saveng;Bumrungsri, Sara;Thomas, Nikky M.
通讯作者：
Thomas, Nikky M.
影响因子：
6.7
作者：
Song, Yanling;Achberger, Christine;Linderholm, Hans W.
通讯作者：
Linderholm, Hans W.
影响因子：
6.6
作者：
Leigh, Jessica W.;Bryant, David
通讯作者：
Bryant, David
影响因子：
1.7
作者：
Gannon, Wumm L.;Sikes, Robept S.
通讯作者：
Sikes, Robept S.